| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
![]() Jameis Winston | 1.Jameis Winston, QB | NYG | L34-27 at DET | 18 | 36 | 366 | 2 | 1 | 1 | 0 | 93.0 |
| 2.Dak Prescott, QB | DAL | W24-21 vs. PHI | 23 | 36 | 354 | 2 | 1 | 1 | 0 | 103.2 | |
| 3.Patrick Mahomes, QB | KC | W23-20 vs. IND | 29 | 46 | 352 | 0 | 1 | 4 | 0 | 77.5 | |
| 4.Jacoby Brissett, QB | ARI | L27-24 vs. JAX | 33 | 49 | 317 | 1 | 0 | 6 | 0 | 92.0 | |
| 5.Drake Maye, QB | NE | W26-20 at CIN | 22 | 35 | 294 | 1 | 1 | 1 | 0 | 87.1 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
![]() Jahmyr Gibbs | 1.Jahmyr Gibbs, RB | DET | W34-27 vs. NYG | 15 | 219 | 14.6 | 2 | 69 | 0 | |
| 2.James Cook III, RB | BUF | L23-19 at HOU | 17 | 116 | 6.8 | 1 | 45 | 0 | ||
| 3.Chase Brown, RB | CIN | L26-20 vs. NE | 19 | 107 | 5.6 | 0 | 21 | 0 | ||
| 4.Emanuel Wilson, RB | GB | W23-6 vs. MIN | 28 | 107 | 3.8 | 2 | 12 | 0 | ||
| 5.Kareem Hunt, RB | KC | W23-20 vs. IND | 30 | 104 | 3.5 | 1 | 18 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
![]() Jaxon Smith-Njigba | 1.Jaxon Smith-Njigba, WR | SEA | W30-24 at TEN | 8 | 167 | 20.9 | 2 | 63 | 0 | |
| 2.Wan'Dale Robinson, WR | NYG | L34-27 at DET | 9 | 156 | 17.3 | 1 | 40 | 0 | ||
| 3.Amon-Ra St. Brown, WR | DET | W34-27 vs. NYG | 9 | 149 | 16.6 | 1 | 30 | 0 | ||
| 4.George Pickens, WR | DAL | W24-21 vs. PHI | 9 | 146 | 16.2 | 1 | 43 | 0 | ||
| 5.Rashee Rice, WR | KC | W23-20 vs. IND | 8 | 141 | 17.6 | 0 | 47 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
![]() Germaine Pratt | 1.Germaine Pratt, LB | IND | L23-20 at KC | 15 | 5 | 20 | 0.0 | 0 | 0 | 0 |
| 2.Blake Cashman, LB | MIN | L23-6 at GB | 8 | 8 | 16 | 0.0 | 0 | 0 | 0 | |
| 3.Barrett Carter, LB | CIN | L26-20 vs. NE | 8 | 8 | 16 | 0.0 | 0 | 0 | 0 | |
| 4.D'Marco Jackson, LB | CHI | W31-28 vs. PIT | 5 | 10 | 15 | 0.0 | 0 | 0 | 0 | |
| 5.Zaire Franklin, LB | IND | L23-20 at KC | 7 | 7 | 14 | 0.0 | 1 | 0 | 0 | |