PDBe›6shs
Electron Microscopy
4.4Å resolution
Source organism:Homo sapiens
Primary publication:
Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue.
Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue.
Related structures:EMD-10204
Function and BiologyDetails
Structure analysisDetails
Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism:Homo sapiens
UniProt:
Sequence domains:Beta-amyloid peptide (beta-APP)
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism:Homo sapiens
UniProt:
- Canonical:
P05067 (Residues: 672-711; Coverage: 5%)
Sequence domains:Beta-amyloid peptide (beta-APP)
Quick links
- 6shs overview
- Structure analysis
- Function and Biology
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Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Assembly composition XML
Assembly 1 (mmCIF; gz)
Assembly 1 (atom only; mmCIF)
FASTA (Entry)
SIFTS XML file with residue-level mappings
Summary report (PDF)
Full report (PDF)
Percentile plot (PNG)
Percentile plot (SVG)
Validation data (XML)
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Assembly composition XML
Assembly 1 (mmCIF; gz)
Assembly 1 (atom only; mmCIF)
FASTA (Entry)
SIFTS XML file with residue-level mappings
Summary report (PDF)
Full report (PDF)
Percentile plot (PNG)
Percentile plot (SVG)
Validation data (XML)
Citations
60 review citations
31 mentions without citation
Challenges in sample preparation and structure determination of amyloids by cryo-EM.
Zielinski et al. (2021)
30 more