›5myo

X-ray diffraction
1.59Å resolution

Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb

Released:
PDB entry 5myo coloured by chain, front view.
PDB entry 5myo coloured by chain, side view.
PDB entry 5myo coloured by chain, top view.

Function and BiologyDetails

Structure analysisDetails

Assemblies composition:
hetero trimer (preferred)
hetero dimer
PDBe Complex ID:
PDB-CPX-209168 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab c#6 light chainChains: A, C
Molecule details ›
Chains: A, C
Length: 219 amino acids
Theoretical weight: 24.17 KDa
Source organism:Mus musculus
Expression system:Mus musculus
    Structure domains:Immunoglobulins
    Fab c#6 heavy chainChains: B, D
    Molecule details ›
    Chains: B, D
    Length: 228 amino acids
    Theoretical weight: 24.68 KDa
    Source organism:Mus musculus
    Expression system:Mus musculus
      Structure domains:Immunoglobulins
      Amyloid-beta protein 40Chain: E
      Molecule details ›
      Chain: E
      Length: 10 amino acids
      Theoretical weight: 1.22 KDa
      Source organism:Homo sapiens
      Expression system: Not provided
      UniProt:
      • Canonical: P05067 (Residues: 674-683; Coverage: 1%)
      Gene names:A4,AD1,APP

      Ligands and Environments

      2 bound ligands:
      1 modified residue:

      Experiments and ValidationDetails

      Entry percentile scores
      X-ray source:RIGAKU MICROMAX-007
      Spacegroup:P1
      Unit cell:
      a: 53.774Å b: 65.958Å c: 67.76Å
      α: 62.87° β: 82.93° γ: 84.11°
      R-values:
      RR workR free
      0.18 0.178 0.215
      Expression systems:
      • Mus musculus
      • Not provided

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