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PDBe›5am8

X-ray diffraction

1.9Å resolution

Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 4-10

Released:13 Jan 2016

DOI:10.2210/pdb5am8/pdb

PDB entry 5am8 coloured by chain, front view.

PDB entry 5am8 coloured by chain, side view.

PDB entry 5am8 coloured by chain, top view.

Source organism:Homo sapiens

Primary publication:
Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme.

LarmuthKM,MasuyerG,DouglasRG,SchwagerSL,AcharyaKR,SturrockED

FEBS J283 1060-76 (2016)

PMID: 26748546

Function and BiologyDetails

Reaction catalysed:

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Biochemical function:

peptidyl-dipeptidase activity

Biological process:

proteolysis

Cellular component:

membrane

Sequence domain:

Peptidase M2, peptidyl-dipeptidase A

Structure analysisDetails

Assembly composition:

hetero dimer (preferred)

Assembly name:

Amyloid-beta protein 40/42 complex and Angiotensin-converting enzyme, soluble form (preferred)
hide full assembly name

PDBe Complex ID:

PDB-CPX-138357 (preferred)

Entry contents:

2 distinct polypeptide molecules

Macromolecules (7 distinct):

Angiotensin-converting enzyme, soluble formChains: A, B, C, D

Molecule details ›

Chains: A, B, C, D
Length: 629 amino acids
Theoretical weight: 72.59 KDa
Source organism:Homo sapiens
Expression system:Cricetulus griseus
UniProt:

Canonical: P12821 (Residues: 30-658; Coverage: 49%)

Gene names:ACE,DCP,DCP1
Sequence domains:Angiotensin-converting enzyme

Amyloid-beta protein 40Chains: P, Q, R, S

Molecule details ›

Chains: P, Q, R, S
Length: 7 amino acids
Theoretical weight: 883 Da
Source organism:Homo sapiens
Expression system: Not provided
UniProt: