›3l81

X-ray diffraction
1.6Å resolution

Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)

Released:
PDB entry 3l81 coloured by chain, front view.
PDB entry 3l81 coloured by chain, side view.
PDB entry 3l81 coloured by chain, top view.

Function and BiologyDetails

Structure analysisDetails

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-126146 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
AP-4 complex subunit mu-1Chain: A
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 33.11 KDa
Source organism:Homo sapiens
Expression system:Escherichia coli
UniProt:
  • Canonical: O00189 (Residues: 160-453; Coverage: 65%)
Gene names:AP4M1,MUARP2
Sequence domains:Adaptor complexes medium subunit family
Structure domains:Mu homology domain, subdomain B
C31Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 963 Da
Source organism:Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 761-767; Coverage: 1%)
Gene names:A4,AD1,APP

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and ValidationDetails

Entry percentile scores
X-ray source:APS BEAMLINE 23-ID-D, APS BEAMLINE 22-ID
Spacegroup:P21
Unit cell:
a: 46.672Å b: 56.91Å c: 60.664Å
α: 90° β: 106.53° γ: 90°
R-values:
RR workR free
0.209 0.207 0.252
Expression systems:
  • Escherichia coli
  • Not provided

PDB-REDO

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