›2r0w

X-ray diffraction
2.5Å resolution

PFA2 FAB complexed with Abeta1-8

Released:
PDB entry 2r0w coloured by chain, front view.
PDB entry 2r0w coloured by chain, side view.
PDB entry 2r0w coloured by chain, top view.

Function and BiologyDetails

Structure analysisDetails

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-106870 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing proteinChain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.2 KDa
Source organism:Mus musculus
UniProt:
  • Canonical: A2NHM3 (Residues: 1-219; Coverage: 100%)
Gene names:Igk-C,Igkc
Sequence domains:
Structure domains:Immunoglobulins
Ig-like domain-containing proteinChain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 24.02 KDa
Source organism:Mus musculus
UniProt:
  • Canonical: Q811U5 (Residues: 1-99, 100-118; Coverage: 100%)
Sequence domains:Immunoglobulin V-set domain
Structure domains:Immunoglobulins
Amyloid-beta protein 40Chain: Q
Molecule details ›
Chain: Q
Length: 8 amino acids
Theoretical weight: 978 Da
Source organism:Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-679; Coverage: 1%)
Gene names:A4,AD1,APP

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and ValidationDetails

Entry percentile scores
X-ray source:RIGAKU
Spacegroup:P1
Unit cell:
a: 42.793Å b: 43.327Å c: 58.456Å
α: 92.51° β: 94.96° γ: 90.55°
R-values:
RR workR free
0.211 0.208 0.277
Expression system: Not provided

PDB-REDO

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