›2fk3

X-ray diffraction
2.4Å resolution

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'large unit cell' form

Released:
PDB entry 2fk3 coloured by chain, front view.
PDB entry 2fk3 coloured by chain, side view.
PDB entry 2fk3 coloured by chain, top view.

Function and BiologyDetails

Structure analysisDetails

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-APPChains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 59 amino acids
Theoretical weight: 6.85 KDa
Source organism:Homo sapiens
Expression system:Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 133-189; Coverage: 8%)
Gene names:A4,AD1,APP
Sequence domains:Copper-binding of amyloid precursor, CuBD
Structure domains:Amyloidogenic glycoprotein, copper-binding domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and ValidationDetails

Entry percentile scores
X-ray source:APS BEAMLINE 14-ID-B
Spacegroup:P212121
Unit cell:
a: 59.623Å b: 67.437Å c: 127.656Å
α: 90° β: 90° γ: 90°
R-values:
RR workR free
0.208 0.208 0.248
Expression system:Komagataella pastoris

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PDB-REDO

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