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Noncanonical agonist-dependent and -independent arrestin recruitment of GPR1. Cai H, Lin Xet al.Science. 2025 Nov 20;390(6775):eadt8794.
High-resolution cryo-EM analysis of the therapeuticPseudomonas phage Pa223. Hou CD, Bellis Net al.J Mol Biol. 2025 Nov 1;437(21):169386.
How augmin establishes the angle of the microtubule branch site. Travis SM, Kraus Jet al.Nat Commun. 2025 Oct 31;16(1):9646.
Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding. Jing T, Shan Zet al.Nat Commun. 2025 Oct 24;16(1):9430.
Crystal structures of agonist-bound human cannabinoid receptor CB1. Hua T, Vemuri Ket al.Nature. 2025 Oct 16;646(8085):754–758.
Previously featured citations...Chimera Search
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September 22, 2025
may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.
March 6, 2025
Chimera production release 1.19 is nowavailable, fixing the ability to fetch structures from the PDB (details...).
December 25, 2024
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please seeChimera commercial licensing.
We encourage Chimera users to tryChimeraX for much better performance with large structures, as well as other majoradvantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from theNational Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
Anisotropic B-factors can be shown as ellipsoids, with ellipsoid axes and radii representing the eigenvectors and eigenvalues of the atomic mean-square displacement matrix. Anisotropic B-factors are read from the input coordinate file (for example, from ANISOU records in a PDB file) and can be displayed with the toolThermal Ellipsoids or the commandaniso. The figure shows ellipsoids scaled to enclose 50% probability for the heme and nearby atoms from PDB entry 1a6m.
(More features...)Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry1qmv), styled as a holiday wreath.
See also theRBVI holiday card gallery.
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