Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | B. PurdyBrock Purdy | M. JonesMac Jones | K. Rourke Knee: NFI-R for Week 13 at Cleveland Knee: NFI-R for Week 13 at Cleveland |
| Running Back | C. McCaffreyChristian McCaffrey | B. Robinson Jr.Brian Robinson Jr. | P. Taylor Shoulder: IR. Injured Reserve Shoulder: IR. Injured Reserve |
| Fullback | K. JuszczykKyle Juszczyk | — | — |
| Wide Receiver | J. JenningsJauan Jennings | R. PearsallRicky Pearsall | B. Aiyuk 49ers' Brandon Aiyuk: Not practicing this week Knee - ACL + MCL: Physically Unable to Perform. Expected Return - Week 15 49ers' Brandon Aiyuk: Not practicing this week Knee - ACL + MCL: Physically Unable to Perform. Expected Return - Week 15 J. Cowing Hamstring: IR. Injured Reserve. Expected Return - Week 15 Hamstring: IR. Injured Reserve. Expected Return - Week 15 T. Taylor Undisclosed: IR. Injured Reserve Undisclosed: IR. Injured Reserve |
| Tight End | G. KittleGeorge Kittle | L. FarrellLuke Farrell | |
| Left Tackle | T. WilliamsTrent Williams | S. BurfordSpencer Burford | — |
| Left Guard | B. BartchBen Bartch | S. BurfordSpencer Burford | |
| Center | J. BrendelJake Brendel | M. HennessyMatt Hennessy | — |
| Right Guard | D. PuniDominick Puni | — | — |
| Right Tackle | C. McKivitzColton McKivitz | A. PleasantsAusten Pleasants | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | B. HuffBryce Huff | K. WhiteKeion White | T. Jackson Undisclosed: IR. Injured Reserve Undisclosed: IR. Injured Reserve |
| Right Defensive End | S. Okuayinonu 49ers' Sam Okuayinonu: Set to miss Week 13 Ankle: Out for Week 13 at Cleveland. Expected Return - Week 15 49ers' Sam Okuayinonu: Set to miss Week 13 Ankle: Out for Week 13 at Cleveland. Expected Return - Week 15 | R. Beal Jr. 49ers' Robert Beal: Full practice Wednesday Concussion: Full Practice on Thursday. Questionable for Week 13 at Cleveland 49ers' Robert Beal: Full practice Wednesday Concussion: Full Practice on Thursday. Questionable for Week 13 at Cleveland | Y. Gross-Matos 49ers' Yetur Gross-Matos: Will remain on IR Knee: IR. Injured Reserve. Expected Return - Week 15 49ers' Yetur Gross-Matos: Will remain on IR Knee: IR. Injured Reserve. Expected Return - Week 15 M. Williams Knee - ACL: IR. Injured Reserve Knee - ACL: IR. Injured Reserve |
| Left Defensive Tackle | K. DavisKalia Davis | K. GivensKevin Givens | — |
| Right Defensive Tackle | A. CollinsAlfred Collins | J. ElliottJordan Elliott | |
| Strongside Linebacker | L. Gifford 49ers' Luke Gifford: Limited to open week Hip: Limited Practice on Thursday. Questionable for Week 13 at Cleveland 49ers' Luke Gifford: Limited to open week Hip: Limited Practice on Thursday. Questionable for Week 13 at Cleveland | — | — |
| Middle Linebacker | T. Bethune 49ers' Tatum Bethune: Logs another DNP Ankle: Did Not Practice on Thursday. Questionable for Week 13 at Cleveland 49ers' Tatum Bethune: Logs another DNP Ankle: Did Not Practice on Thursday. Questionable for Week 13 at Cleveland | C. RobinsonCurtis Robinson | F. Warner Ankle: IR. Injured Reserve Ankle: IR. Injured Reserve |
| Weakside Linebacker | D. WintersDee Winters | N. MartinNick Martin | — |
| Right Cornerback | D. LenoirDeommodore Lenoir | D. Luter Jr.Darrell Luter Jr. | J. Robinson Forearm: IR. Injured Reserve Forearm: IR. Injured Reserve |
| Left Cornerback | R. GreenRenardo Green | T. Hodges-Tomlinson Undisclosed: IR. Injured Reserve Undisclosed: IR. Injured Reserve | — |
| Slot Cornerback | U. Stout 49ers' Upton Stout: Tallies six stops 49ers' Upton Stout: Tallies six stops | C. LucasChase Lucas | — |
| Strong Safety | J. BrownJi'Ayir Brown | J. PinnockJason Pinnock | — |
| Free Safety | M. MustaphaMalik Mustapha | M. SigleMarques Sigle |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | T. MorsteadThomas Morstead | — | — |
| Kicker | E. Pineiro 49ers' Eddy Pineiro: Logs another DNP Hamstring: Did Not Practice on Thursday. Questionable for Week 13 at Cleveland 49ers' Eddy Pineiro: Logs another DNP Hamstring: Did Not Practice on Thursday. Questionable for Week 13 at Cleveland | — | — |
| Long Snapper | J. WeeksJon Weeks | — | — |
| Holder | T. MorsteadThomas Morstead | — | — |
| Punt Returner | S. MooreSkyy Moore | J. WatkinsJordan Watkins | J. Cowing Hamstring: IR. Injured Reserve. Expected Return - Week 15 Hamstring: IR. Injured Reserve. Expected Return - Week 15 |
| Kick Returner | S. MooreSkyy Moore | I. GuerendoIsaac Guerendo | — |