Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | B. YoungBryce Young | A. DaltonAndy Dalton | — |
| Running Back | R. DowdleRico Dowdle | C. HubbardChuba Hubbard | J. Brooks Knee - ACL: Physically Unable to Perform Knee - ACL: Physically Unable to Perform |
| Wide Receiver | T. McMillanTetairoa McMillan | X. LegetteXavier Legette | D. Moore Elbow: IR. Injured Reserve. Expected Return - Week 15 Elbow: IR. Injured Reserve. Expected Return - Week 15 |
| Tight End | J. SandersJa'Tavion Sanders | T. TrembleTommy Tremble | |
| Left Tackle | I. EkwonuIkem Ekwonu | Y. NijmanYosh Nijman | — |
| Left Guard | D. LewisDamien Lewis | A. CorbettAustin Corbett | — |
| Center | C. Mays Panthers' Cade Mays: DNP on Wednesday Ankle: Full Practice on Thursday. Questionable for Week 13 vs. L.A. Rams Panthers' Cade Mays: DNP on Wednesday Ankle: Full Practice on Thursday. Questionable for Week 13 vs. L.A. Rams | A. CorbettAustin Corbett | |
| Right Guard | C. Zavala Panthers' Chandler Zavala: Misses practice Wednesday Calf: Did Not Practice on Thursday. Questionable for Week 13 vs. L.A. Rams Panthers' Chandler Zavala: Misses practice Wednesday Calf: Did Not Practice on Thursday. Questionable for Week 13 vs. L.A. Rams | J. CurhanJake Curhan | R. Hunt Biceps: IR. Injured Reserve. Expected Return - Week 15 Biceps: IR. Injured Reserve. Expected Return - Week 15 B. Christensen Achilles: IR. Injured Reserve Achilles: IR. Injured Reserve |
| Right Tackle | T. MotonTaylor Moton | Y. NijmanYosh Nijman | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | T. WhartonTershawn Wharton | B. Brown IIIBobby Brown III | P. Aumavae Achilles: IR. Injured Reserve Achilles: IR. Injured Reserve |
| Nose Tackle | A. RobinsonA'Shawn Robinson | B. Brown IIIBobby Brown III | |
| Right Defensive End | D. BrownDerrick Brown | L. RayLaBryan Ray | |
| Left Inside Linebacker | C. Rozeboom Panthers' Christian Rozeboom: Fails to participate again Hip: Did Not Practice on Thursday. Questionable for Week 13 vs. L.A. Rams Panthers' Christian Rozeboom: Fails to participate again Hip: Did Not Practice on Thursday. Questionable for Week 13 vs. L.A. Rams | M. NjongmetaMaema Njongmeta | |
| Right Inside Linebacker | T. Wallace Panthers' Trevin Wallace: Full practice Wednesday Panthers' Trevin Wallace: Full practice Wednesday | C. Cherelus Panthers' Claudin Cherelus: Misses practice Wednesday Concussion: Did Not Practice on Thursday. Questionable for Week 13 vs. L.A. Rams Panthers' Claudin Cherelus: Misses practice Wednesday Concussion: Did Not Practice on Thursday. Questionable for Week 13 vs. L.A. Rams | |
| Strongside Linebacker | D. WonnumD.J. Wonnum | P. UmanmielenPrincely Umanmielen | |
| Weakside Linebacker | N. ScourtonNic Scourton | T. GipsonTrevis Gipson | P. Jones II Back: IR. Injured Reserve Back: IR. Injured Reserve |
| Right Cornerback | J. Horn Panthers' Jaycee Horn: Absent from walkthrough Concussion: Did Not Practice on Thursday. Questionable for Week 13 vs. L.A. Rams Panthers' Jaycee Horn: Absent from walkthrough Concussion: Did Not Practice on Thursday. Questionable for Week 13 vs. L.A. Rams | R. RochellRobert Rochell | C. Thornton Panthers' Corey Thornton: Shifting to IR Lower Leg: IR. Injured Reserve Panthers' Corey Thornton: Shifting to IR Lower Leg: IR. Injured Reserve |
| Left Cornerback | M. JacksonMike Jackson | A. EvansAkayleb Evans | D. Mathis Knee - ACL: IR. Injured Reserve Knee - ACL: IR. Injured Reserve |
| Slot Cornerback | C. Smith-WadeChau Smith-Wade | — | — |
| Strong Safety | T. Moehrig Panthers' Tre'von Moehrig: Suspension upheld Suspension: Suspended until Week 15 at New Orleans Panthers' Tre'von Moehrig: Suspension upheld Suspension: Suspended until Week 15 at New Orleans | D. RichardsonDemani Richardson | — |
| Free Safety | N. ScottNick Scott | L. RansomLathan Ransom | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | S. MartinSam Martin | — | — |
| Kicker | R. FitzgeraldRyan Fitzgerald | — | — |
| Long Snapper | J. JansenJ.J. Jansen | — | — |
| Holder | S. MartinSam Martin | — | — |
| Punt Returner | T. EtienneTrevor Etienne | H. RenfrowHunter Renfrow | |
| Kick Returner | T. EtienneTrevor Etienne | C. HubbardChuba Hubbard |