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mitoClone2

This is thereleased version of mitoClone2; for the devel version, seemitoClone2.

Clonal Population Identification in Single-Cell RNA-Seq Data using Mitochondrial and Somatic Mutations

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DOI: 10.18129/B9.bioc.mitoClone2


Bioconductor version: Release (3.22)

This package primarily identifies variants in mitochondrial genomes from BAM alignment files. It filters these variants to remove RNA editing events then estimates their evolutionary relationship (i.e. their phylogenetic tree) and groups single cells into clones. It also visualizes the mutations and providing additional genomic context.

Author: Benjamin Story [aut, cre], Lars Velten [aut], Gregor Mönke [aut]

Maintainer: Benjamin Story <story.benjamin at gmail.com>

Citation (from within R, entercitation("mitoClone2")):

Installation

To install this package, start R (version "4.5") and enter:

if (!require("BiocManager", quietly = TRUE))    install.packages("BiocManager")BiocManager::install("mitoClone2")

For older versions of R, please refer to the appropriateBioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("mitoClone2")
Computation of phylogenetic trees and clustering of mutationsHTMLR Script
Variant CallingHTMLR Script
Reference ManualPDF
NEWSText

Need some help? Ask on the Bioconductor Support site!

Details

biocViewsAlignment,Annotation,DataImport,Genetics,SNP,SingleCell,Software
Version1.16.0
In Bioconductor sinceBioC 3.14 (R-4.1) (4 years)
LicenseGPL-3
DependsR (>= 4.4.0)
Importsreshape2,GenomicRanges,pheatmap,deepSNV, grDevices,Matrix, graphics, stats, utils,S4Vectors,Rhtslib, parallel, methods,ggplot2
System RequirementsGNU make, PhISCS (optional)
URLhttps://github.com/benstory/mitoClone2
See More
Suggestsknitr,rmarkdown,Biostrings,testthat
Linking ToRhtslib(>= 1.13.1)
Enhances
Depends On Me
Imports Me
Suggests Me
Links To Me
Build ReportBuild Report

Package Archives

FollowInstallation instructions to use this package in your R session.

Source PackagemitoClone2_1.16.0.tar.gz
Windows Binary (x86_64) mitoClone2_1.16.0.zip
macOS Binary (x86_64)mitoClone2_1.16.0.tgz
macOS Binary (arm64)mitoClone2_1.16.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/mitoClone2
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/mitoClone2
Bioc Package Browserhttps://code.bioconductor.org/browse/mitoClone2/
Package Short Urlhttps://bioconductor.org/packages/mitoClone2/
Package Downloads ReportDownload Stats

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