dinoR
This is thereleased version of dinoR; for the devel version, seedinoR.
Differential NOMe-seq analysis
Bioconductor version: Release (3.22)
dinoR tests for significant differences in NOMe-seq footprints between two conditions, using genomic regions of interest (ROI) centered around a landmark, for example a transcription factor (TF) motif. This package takes NOMe-seq data (GCH methylation/protection) in the form of a Ranged Summarized Experiment as input. dinoR can be used to group sequencing fragments into 3 or 5 categories representing characteristic footprints (TF bound, nculeosome bound, open chromatin), plot the percentage of fragments in each category in a heatmap, or averaged across different ROI groups, for example, containing a common TF motif. It is designed to compare footprints between two sample groups, using edgeR's quasi-likelihood methods on the total fragment counts per ROI, sample, and footprint category.
Author: Michaela Schwaiger [aut, cre]
ORCID: 0000-0002-4522-7810
Maintainer: Michaela Schwaiger <michaela.schwaiger at fmi.ch>
citation("dinoR")):Installation
To install this package, start R (version "4.5") and enter:
if (!require("BiocManager", quietly = TRUE)) install.packages("BiocManager")BiocManager::install("dinoR")For older versions of R, please refer to the appropriateBioconductor release.
Documentation
To view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("dinoR")| dinoR-vignette | HTML | R Script |
| Reference Manual | ||
| NEWS | Text | |
| LICENSE | Text |
Details
| biocViews | Coverage,DifferentialMethylation,Epigenetics,MethylSeq,NucleosomePositioning,Sequencing,Software,Transcription |
| Version | 1.6.0 |
| In Bioconductor since | BioC 3.19 (R-4.4) (1.5 years) |
| License | MIT + fileLICENSE |
| Depends | R (>= 4.3.0),SummarizedExperiment |
| Imports | BiocGenerics,circlize,ComplexHeatmap,cowplot,dplyr,edgeR,GenomicRanges,ggplot2,Matrix, methods,rlang, stats,stringr,tibble,tidyr,tidyselect |
| System Requirements | |
| URL | https://github.com/xxxmichixxx/dinoR |
| Bug Reports | https://github.com/xxxmichixxx/dinoR/issues |
See More
| Suggests | knitr,rmarkdown,testthat (>= 3.0.0) |
| Linking To | |
| Enhances | |
| Depends On Me | |
| Imports Me | |
| Suggests Me | |
| Links To Me | |
| Build Report | Build Report |
Package Archives
FollowInstallation instructions to use this package in your R session.
| Source Package | dinoR_1.6.0.tar.gz |
| Windows Binary (x86_64) | dinoR_1.6.0.zip |
| macOS Binary (x86_64) | dinoR_1.6.0.tgz |
| macOS Binary (arm64) | dinoR_1.6.0.tgz |
| Source Repository | git clone https://git.bioconductor.org/packages/dinoR |
| Source Repository (Developer Access) | git clone git@git.bioconductor.org:packages/dinoR |
| Bioc Package Browser | https://code.bioconductor.org/browse/dinoR/ |
| Package Short Url | https://bioconductor.org/packages/dinoR/ |
| Package Downloads Report | Download Stats |