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CNVPanelizer

This is thereleased version of CNVPanelizer; for the devel version, seeCNVPanelizer.

Reliable CNV detection in targeted sequencing applications

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DOI: 10.18129/B9.bioc.CNVPanelizer


Bioconductor version: Release (3.22)

A method that allows for the use of a collection of non-matched normal tissue samples. Our approach uses a non-parametric bootstrap subsampling of the available reference samples to estimate the distribution of read counts from targeted sequencing. As inspired by random forest, this is combined with a procedure that subsamples the amplicons associated with each of the targeted genes. The obtained information allows us to reliably classify the copy number aberrations on the gene level.

Author: Cristiano Oliveira [aut], Thomas Wolf [aut, cre], Albrecht Stenzinger [ctb], Volker Endris [ctb], Nicole Pfarr [ctb], Benedikt Brors [ths], Wilko Weichert [ths]

Maintainer: Thomas Wolf <thomas_wolf71 at gmx.de>

Citation (from within R, entercitation("CNVPanelizer")):

Installation

To install this package, start R (version "4.5") and enter:

if (!require("BiocManager", quietly = TRUE))    install.packages("BiocManager")BiocManager::install("CNVPanelizer")

For older versions of R, please refer to the appropriateBioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("CNVPanelizer")
CNVPanelizerPDFR Script
Reference ManualPDF
NEWSText

Need some help? Ask on the Bioconductor Support site!

Details

biocViewsClassification,CopyNumberVariation,Coverage,Normalization,Sequencing,Software
Version1.42.0
In Bioconductor sinceBioC 3.2 (R-3.2) (10 years)
LicenseGPL-3
DependsR (>= 3.2.0),GenomicRanges
ImportsBiocGenerics,S4Vectors, grDevices, stats, utils,NOISeq,IRanges,Rsamtools,foreach,ggplot2,plyr,GenomeInfoDb,gplots,reshape2,stringr,testthat, graphics, methods,shiny,shinyFiles,shinyjs, grid,openxlsx
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Package Archives

FollowInstallation instructions to use this package in your R session.

Source PackageCNVPanelizer_1.42.0.tar.gz
Windows Binary (x86_64) CNVPanelizer_1.42.0.zip (64-bit only)
macOS Binary (x86_64)CNVPanelizer_1.42.0.tgz
macOS Binary (arm64)CNVPanelizer_1.42.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/CNVPanelizer
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/CNVPanelizer
Bioc Package Browserhttps://code.bioconductor.org/browse/CNVPanelizer/
Package Short Urlhttps://bioconductor.org/packages/CNVPanelizer/
Package Downloads ReportDownload Stats

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