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Ventrolateral medulla

From Wikipedia, the free encyclopedia

Theventrolateral medulla, part of themedulla oblongata of thebrainstem, plays a major role in regulatingarterial blood pressure andbreathing. It regulates blood pressure by regulating the activity of thesympathetic nerves that target the heart and peripheralblood vessels.[1]

The ventrolateral medulla consists of arostral ventrolateral medulla (RVLM) and acaudal ventrolateral medulla (CVLM).[2] Neurons in the RVLM project directly to preganglionic neurons in thespinal cord and maintaintonic activity in the sympatheticvasomotor nerves. This activity is inhibited byGABA output from the CVLM.[3][4]

References

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  1. ^Ann M. Schreihofer; Alan F. Sved (2011). "The Ventrolateral Medulla and Sympathetic Regulation of Arterial Pressure". In Ida J. Llewellyn-Smith; Anthony J. M. Verberne (eds.).Central Regulation of Autonomic Functions. pp. 78–97.doi:10.1093/acprof:oso/9780195306637.003.0005.ISBN 978-0-19-530663-7.
  2. ^Campos, RR; Carillo, BA; Oliveira-Sales, EB; Silva, AM; Silva, NF; Futuro Neto, HA; Bergamaschi, CT (July 2008)."Role of the caudal pressor area in the regulation of sympathetic vasomotor tone".Brazilian Journal of Medical and Biological Research.41 (7):557–62.doi:10.1590/s0100-879x2008000700002.PMID 18719736.
  3. ^Dampney, RA; Horiuchi, J; Tagawa, T; Fontes, MA; Potts, PD; Polson, JW (March 2003). "Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone".Acta Physiologica Scandinavica.177 (3):209–18.doi:10.1046/j.1365-201X.2003.01070.x.PMID 12608991.
  4. ^Sved, AF; Ito, S; Madden, CJ; Stocker, SD; Yajima, Y (June 2001). "Excitatory inputs to the RVLM in the context of the baroreceptor reflex".Annals of the New York Academy of Sciences.940 (1):247–58.Bibcode:2001NYASA.940..247S.doi:10.1111/j.1749-6632.2001.tb03681.x.PMID 11458682.S2CID 32160703.


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