 | This articleneeds additional citations forverification. Please helpimprove this article byadding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "U.S. Route 22 in Pennsylvania" – news ·newspapers ·books ·scholar ·JSTOR(May 2022) (Learn how and when to remove this message) |
 U.S. Route 22 | ||||
|---|---|---|---|---|
 US 22 highlighted in red and business routes in blue | ||||
| Route information | ||||
| Maintained byPennDOT andDRJTBC | ||||
| Length | 338.20 mi[1] (544.28 km) | |||
| Existed | 1926–present | |||
| Major junctions | ||||
| West end |  US 22 at theWest Virginia state line | |||
| Major intersections |
| |||
| East end | US 22 at theNew Jersey state line | |||
| Location | ||||
| Country | United States | |||
| State | Pennsylvania | |||
| Counties | Washington,Allegheny,Westmoreland,Indiana,Cambria,Blair,Huntingdon,Mifflin,Juniata,Perry,Dauphin,Lebanon,Berks,Lehigh,Northampton | |||
| Highway system | ||||
| ||||
U.S. Route 22 (US 22) is an east–westUnited States Numbered Highway that stretches fromCincinnati, Ohio, in the west, toNewark, New Jersey, in the east. InPennsylvania, the route runs for 338.20 miles (544.28 km) between theWest Virginia state line inWashington County, where it is afreeway through the western suburbs ofPittsburgh, and then runs east toEaston and the Pennsylvania–New Jersey state line in theLehigh Valley region of eastern Pennsylvania.
Much of US 22 in Pennsylvania follows the route of the historicWilliam Penn Highway. The portion from thePennsylvania Route 66 (PA 66) interchange nearDelmont east to theInterstate 81 (I-81) interchange nearHarrisburg is the main part ofCorridor M of theAppalachian Development Highway System, although a large portion near the center of the route has not yet been upgraded to a four-lane divided highway.[2][3]
BetweenFredericksburg and just west ofAllentown, US 22runs concurrently withI-78. From Allentown to the New Jersey state line, the route is a freeway named theLehigh Valley Thruway.
US 22 enters Pennsylvania fromWest Virginia inWashington County, heading east as a four-lanefreeway namedWilliam Penn Highway. The route runs through rural areas with some development, curving northeast and then east again before coming to apartial cloverleaf interchange withPA 18 nearThe Pavilion at Star Lake. Past this interchange, the freeway continues east and crossesRaccoon Creek before curving southeast and reaching adiamond interchange with Maple Grove Road that serves Bavington, Pennsylvania.[4][5]
Following this, US 22 heads east again and comes to athree-level diamond interchange with thePA 576 toll road.[4][5]
US 22 entersAllegheny County and immediately reaches a partial cloverleaf interchange with the northern terminus ofPA 980, where it also passes over theMontour Trail. From here, the freeway continues east through rural land with some development to a partial cloverleaf interchange with Kelso Road that provides access toNoblestown. The route curves northeast and reaches a partial cloverleaf interchange withUS 30 and the northern terminus ofPA 978.[4][5]
At this point, US 30 heads east for aconcurrency with US 22. US 22/US 30 run east as a four-lane freeway through suburban areas, coming to a partial cloverleaf interchange with Oakdale Road that serves Hankey Farms. Farther east, the freeway has a westbound exit and eastbound entrance with McKee Road that provides access to the borough ofOakdale to the south. From here, US 22/US 30 turn east-northeast and reach an interchange that connects to Old Steubenville Pike, Bayer Road, and Montour Church Road. The freeway comes to an interchange withI-376, where US 22/US 30 head southeast concurrent with I-376 andPA 60 continues east (south) at-grade along a four-lane divided highway.[4][5]
I-376/US 22/US 30 head southeast as the four-lane Penn-Lincoln Parkway, reaching an interchange with Ridge Road. The freeway comes to a westbound exit and eastbound entrance with Campbells Run Road, where it widens to six lanes. The highway curves to the east and meetsI-79 at an interchange.[4][5]
Past this interchange, I-376/US 22/US 30 narrows to two lanes eastbound and head into the borough ofRosslyn Farms, turning southeast and coming to a westbound exit and eastbound entrance with Rosslyn Road that serves Rosslyn Farms. The freeway crosses into the borough ofCarnegie and reaches a bus-only eastbound exit and westbound entrance connecting toPittsburgh Regional Transit (PRT)'sWest Busway before passing over aPittsburgh and Ohio Central Railroad line. The highway passes overChartiers Creek and another Pittsburgh and Ohio Central Railroad line as it leaves Carnegie and comes to thePA 50 interchange.[4][5]
I-376/US 22/US 30 narrows to four lanes, passing under aWheeling and Lake Erie Railway line and curving northeast into the borough ofGreen Tree. The freeway reaches thePA 121 interchange, where it gains a third westbound lane, and heads east, enteringPittsburgh and coming to a westbound exit and eastbound entrance with Parkway Center Drive.
The highway turns north and reaches a westbound exit and eastbound entrance withUS 19, where US 19 joins I-376/US 22/US 30 on the Penn-Lincoln Parkway. Within this interchange, the road has an eastboundrunaway truck ramp and passes under a ramp carrying both directions ofUS 19 Truck.[4][5]
The freeway widens to six lanes and passes under a Wheeling and Lake Erie Railway line before reaching an interchange withPA 51, where US 19 Truck joins the Penn-Lincoln Parkway from PA 51 and US 19 splits from the Penn-Lincoln Parkway by heading north along with PA 51. Past this interchange, I-376/US 22/US 30/US 19 Truck narrows to four lanes and passes underMount Washington in theFort Pitt Tunnel.[4][5]
After emerging from the Fort Pitt Tunnel, the freeway passes overNorfolk Southern Railway'sMon Line andPA 837, coming to a westbound exit and eastbound entrance that connects to northbound PA 837. The Penn-Lincoln Parkway heads onto theFort Pitt Bridge, a double-decker bridge carrying four lanes in each direction, and passes overCSX Transportation'sPittsburgh Subdivision railroad line and theMonongahela River as it heads intoDowntown Pittsburgh atPoint State Park and comes to an interchange with the southern terminus ofI-279, where US 19 Truck heads north along I-279 and I-376/US 22/US 30 continue east along the Penn-Lincoln Parkway. The I-279 interchange also includes eastbound exits and westbound entrances withBoulevard of the Allies/Liberty Avenue and Fort Duquesne Boulevard that serve Downtown Pittsburgh. The four-lane freeway heads east-southeast between Downtown Pittsburgh to the north and the Monongahela River to the south, reaching a partial interchange with Stanwix Street with no eastbound exit. The highway heads under theSmithfield Street Bridge and comes to an interchange with Grant Street, where it widens to six lanes. I-376/US 22/US 30 pass under thePanhandle Bridge carrying PRT'sPittsburgh Light Rail line and then theLiberty Bridge before the lanes split as it reaches a westbound ramp to Second Avenue north of theSouth Tenth Street Bridge and south of theDuquesne University campus.[4][5]
Past this, the highway continues east between urban areas to the north and the Monongahela River to the south, with theThree Rivers Heritage Trail in the median. The freeway comes to an interchange connecting toPA 885 and Forbes Avenue north of theBirmingham Bridge, at which point the trail leaves the median of the freeway and the river heads further south from the freeway. I-376/US 22/US 30 head southeast, with the Three Rivers Heritage Trail parallel to the south, and reaches a westbound exit and eastbound entrance with PA 885. The highway turns east away from the trail and passes over theAllegheny Valley Railroad'sP&W Subdivision line. The freeway comes to an interchange with Beechwood Boulevard before it narrows to four lanes and passes under the southern portion ofSquirrel Hill in theSquirrel Hill Tunnel. Past the tunnel, I-376/US 22/US 30 head through wooded areas and pass over Ninemile Run inFrick Park. The highway leaves Pittsburgh as it comes to an interchange with Braddock Avenue that serves the boroughs ofEdgewood andSwissvale. The freeway continues east through suburban areas in Edgewood, passing under Norfolk Southern Railway'sPittsburgh Line and PRT'sMartin Luther King Jr. East Busway. I-376/US 22/US 30 turn to the northeast and head through a corner of the borough ofBraddock Hills before entering the borough ofWilkinsburg. In Wilkinsburg, the freeway comes to an interchange with the southern terminus ofPA 8, where US 30 splits from I-376/US 22 on the Penn-Lincoln Parkway by heading southeast at-grade on Ardmore Boulevard.[4][5]
Past this interchange, I-376/US 22 continue northeast through suburban development, crossing into the borough ofChurchill and reaching an eastbound exit and westbound entrance with Greensburg Pike. From here, the freeway narrows to four lanes and curves east, coming to an interchange withPA 130. The highway widens back to six lanes and continues southeast, reaching an interchange serving the western terminus ofUS 22 Business (US 22 Bus.) andPA 791, where it turns to the east and leaves Churchill. I-376/US 22 continue east through suburbs and the road enters the borough ofMonroeville upon crossing over Thompson Run and aUnion Railroad line. The freeway curves southeast and comes to an interchange providing access to the eastern terminus of US 22 Bus.,PA 48, and thePennsylvania Turnpike (I-76) at the Pittsburgh interchange. At this point, US 22 splits from I-376, which ends at the Pennsylvania Turnpike (I-76), and continues east along William Penn Highway, a four-lanedivided highway with at-grade intersections. The road runs through suburban development, curving southeast and reaching an interchange with the western terminus ofPA 286 that consists of an eastbound exit and westbound entrance, with the westbound exit and eastbound entrance provided by an at-grade intersection with a short connector. Past PA 286, the route winds to the east.[4][5]
US 22 leaves Monroeville and enters the borough ofMurrysville inWestmoreland County, where it continues east through suburban areas along William Penn Highway, a four-lane divided highway with occasionaljughandles. The road curves to the east-southeast and passes over theWestmoreland Heritage Trail andTurtle Creek. The route continues past a mix of rural areas and development, passing to the south of the borough ofExport and crosses Turtle Creek again before leaving Murrysville. US 22 curves east and comes to asingle-point urban interchange withPA 66 south of the borough ofDelmont. Past this interchange, the road runs east-northeast through rural areas with occasional development, turning east and coming to an intersection withPA 819 in Five Points. The route continues east and reaches a junction withUS 119 nearShieldsburg. At this point, US 119 turns east to run concurrent with US 22 along William Penn Highway. The road comes to a bridge overLoyalhanna Creek within the Loyalhanna Lake National Recreation Area and enters the borough ofNew Alexandria. At this point, the two routes pass north of developed areas of the borough and reach an intersection withPA 981 along the northern border of New Alexandria. From here, US 22/US 119 continue northeast through rural land with some development, passing to the north of Keystone Raceway. The road curves to the east and comes to a junction with the northern terminus ofPA 982. Past this intersection, the two routes run through more rural areas, curving back to the northeast.[4][5]
Upon crossing theConemaugh River, US 22/US 119 enter the borough ofBlairsville inIndiana County and pass over Norfolk Southern Railway'sConemaugh Line before reaching an interchange withPA 217. The road runs east through developed areas, passing over Lear Road, before it leaves Blairsville and comes to a bridge over Norfolk Southern Railway's Blairsville Industrial Track line. The two routes run east-northeast through commercial areas before coming to a partial cloverleaf interchange where US 119 splits from US 22 by heading to the northeast. From here, US 22 continues east along four-lane divided William Penn Highway through rural areas with occasional development, crossingChestnut Ridge. Farther east, the route curves to the southeast and reaches an interchange withPA 259. The road turns back to the east and passes south ofClyde. US 22 intersects West Philadelphia Street, which heads east to the borough ofArmagh, and becomes a freeway that bypasses Armagh to the north. The route comes to a partial cloverleaf interchange withPA 56 that provides access to Armagh. The road continues east and has an eastboundright-in/right-out interchange with East Philadelphia Street before it reaches a partial cloverleaf interchange withPA 403. At the PA 403 interchange, the freeway section ends and US 22 continues east-southeast as a four-lane divided highway with at-grade intersections through rural land with some development.[4][5]
.jpg)
US 22 crosses intoCambria County, where the name of the road becomes Admiral Peary Highway. The route gains a third eastbound lane as it ascendsLaurel Ridge. The road comes to a partial cloverleaf interchange with Dishong Mountain Road. Past this interchange, US 22 turns east-northeast and reaches the summit of the ridge before it descends Laurel Ridge as a four-lane divided highway, passing through a section ofGallitzin State Forest. The route continues through rural areas with some development and passes throughChickaree before curving to the east. The road comes to a partial cloverleaf interchange withPA 271 south of the borough ofNanty Glo. Past this interchange, US 22 continues east through rural land, turning to the northeast. The route heads near development and passes southeast ofEbensburg Airport before it reaches acloverleaf interchange with theUS 219 freeway. The road runs through commercial areas and comes to a partialtrumpet interchange with High Street that provides access to the borough ofEbensburg; this interchange has no westbound exit. At this point, US 22 curves to the east and bypasses Ebensburg to the south by running along its southern border, passing overPA 160 with no access. The road runs near developed areas and comes to a partial cloverleaf interchange with Rowena Drive/Admiral Peary Highway on the eastern edge of Ebensburg. Following this interchange, the route becomes an unnamed four-lane freeway and continues east through rural areas, passing under an abandoned railroad line. US 22 turns southeast and makes a curve to the east before reaching a diamond interchange with the western terminus ofPA 164 nearMunster. The freeway continues southeast and passes over Norfolk Southern Railway's Pittsburgh Line prior to coming to a partial cloverleaf interchange withPA 53 south of the borough ofCresson. The route curves to the northeast and reaches a diamond interchange with Admiral Peary Highway east of Cresson. Following this interchange, US 22 makes a turn to the east and comes to a partial cloverleaf interchange with Tunnelhill Road south of the borough ofTunnelhill that provides access to theAllegheny Portage Railroad National Historic Site to the south.[4][5]
At the interchange with Tunnelhill Road, US 22 entersBlair County and begins to descend throughBlair Gap, heading northeast before winding to the east as it heads through rural areas. The freeway turns to the southeast and heads into developed areas to the south ofAltoona. US 22 comes to a doubletrumpet interchange with the southern terminus ofPA 764, where US 22 splits to the south onto an unnamed four-lane divided highway with at-grade intersections while the freeway continues east to an interchange withI-99/US 220. The route heads south-southwest through a mix of rural areas and development, with two sections where the median turns into acenter left-turn lane. The four-lane divided highway curves to the east-southeast and comes to an intersection withUS 220 Bus., which heads to the south. At this point, US 22 turns east-northeast for a concurrency with US 220 Bus. on two-lane undivided 3rd Avenue, entering the borough ofDuncansville. The road runs through developed areas of the borough, passing under I-99/US 220. The two routes gain a center left-turn lane and leave Duncansville, crossing a Norfolk Southern Railway line and then Norfolk Southern Railway's Cove Secondary railroad line at-grade before US 220 Bus. splits from US 22 by heading to the north. From here, US 22 heads east as Broad Street as it runs parallel to the Cove Secondary to the south, entering the borough ofHollidaysburg. The road narrows to two lanes before it crosses Beaverdam Branch and becomes South Juniata Street. The route turns east-northeast onto Blair Street and heads away from the railroad tracks, coming to an intersection withPA 36. US 22 turns northeast and runs between developed areas to the northwest and a railroad yard to the southeast before it crosses a Norfolk Southern Railway spur at-grade and curves east, leaving Hollidaysburg.[4][5]
East of Hollidaysburg, US 22 becomes an unnamed two-lane undivided road and heads into rural areas with some development, curving northeast and passing throughFrankstown, where it briefly gains a center left-turn lane. The road runs throughGeeseytown before it turns east and gains a second eastbound lane, bending back to the northeast again. The route narrows back to two lanes and heads throughCanoe Creek, where it passes to the south ofCanoe Creek State Park. US 22 continues northeast and runs parallel to theFrankstown Branch Juniata River to the southeast, heading away from the river before reaching an intersection with the northern terminus ofPA 866. Past this intersection, the road widens to four lanes and curves to the north, turning to the east as it passes to the south ofCanoe Mountain. The route makes a curve to the northeast and narrows to one eastbound lane and then one westbound lane a short distance later, heading into the Canoe Valley. US 22 briefly gains a second westbound lane before passing throughYellow Springs. The road continues northeast through rural land, gaining a second westbound lane for a short stretch before it becomes two lanes again.[4][5]
US 22 entersHuntingdon County and continues northeast through rural areas along William Penn Highway, briefly widening to two eastbound lanes. The route turns into a three-lane road with two westbound lanes and one westbound lane, passing over Goodman and Shaffersville roads before reaching an intersection with the southern terminus ofPA 453 inWater Street. US 22 curves east as a three-lane road with a center left-turn lane and runs a short distance to the north of the Frankstown Branch Juniata River, passing through a gap inTussey Mountain. The road turns to the southeast and crosses the river nearAlfarata, continuing though rural land with some development and coming to an intersection with the western terminus ofPA 305 south of the borough ofAlexandria. The route curves south and becomes a four-lane undivided road. US 22 turns to the southeast and narrows to one eastbound lane as it traversesWarrior Ridge, briefly becoming a two-lane road before gaining a second eastbound lane. Farther southeast, the road heads into commercial areas and turns into a four-lane divided highway as it comes to a partial cloverleaf interchange withPA 26. The route turns into a three-lane road with a center left-turn lane that bypasses the borough ofHuntingdon to the south, passing over a Norfolk Southern Railway spur and reaching an interchange with Fairgrounds Road consisting of a two-wayquadrant ramp. The road curves east and passes over theJuniata River and Norfolk Southern Railway's Pittsburgh Line before coming to an interchange with Penn Street that provides access to Huntingdon and PA 26.[4][5]
Past this interchange, US 22 turns to the southeast and runs parallel to the Juniata River and the Pittsburgh Line, running through rural areas with some development as a three-lane road with two westbound lanes and one eastbound lane and passing over Numers Hollow Road, where it becomes three lanes with a center left-turn lane. The route passes throughArdenheim before it curves more to the east and reaches an intersection with the northern terminus ofPA 829. The road curves southeast and enters the borough ofMill Creek, running through developed areas and coming to a junction withPA 655. At this point, PA 655 joins US 22 in a concurrency and the two routes head south-southeast. The road narrows to two lanes before it leaves Mill Creek, where it heads south thorough rural areas to the east of the river and railroad line and gains a second westbound lane before becoming three lanes with two eastbound lanes and one westbound lane. PA 655 splits from US 22 by heading to the southwest, with US 22 continuing south and briefly becoming four lanes before narrowing to one lane eastbound. The route turns to the east and briefly becomes three lanes with a center turn lane before narrowing to two lanes and running east through a gap inJacks Mountain a short distance to the north of the Juniata River and the Pittsburgh Line. Farther east, the road gains a second westbound lane.[4][5]
US 22 entersMifflin County and becomes an unnamed three-lane road with a center left-turn lane, passing throughLucy Furnace and coming to an intersection with the northern terminus ofPA 747. Following this, the route becomes a four-lane road and turns into a divided highway before it reaches a junction withUS 522 north of the borough ofMount Union on the opposite side of the Juniata River. At this point, US 522 joins US 22 in a concurrency and the road becomes undivided again, turning to the north and narrowing to two lanes. The road runs through rural areas with some development in a valley between Jacks Mountain to the northwest and the Juniata River further to the southeast, curving to the northeast. US 22/US 522 passes throughAtkinson Mills before it enters the borough ofMcVeytown. Here, the road gains a center left-turn lane and heads through developed areas, curving to the north and running a short distance to the west of the Juniata River. The two routes leave McVeytown and narrow to two lanes, turning northeast to pass through more rural land to the northwest of the river. US 22/US 522 runs further northwest from the Juniata River. The road gains a center left-turn lane and continues through a mix of rural areas and development, heading throughStrodes Mills before losing the center turn lane. Farther northeast, US 22/US 522 turns into a four-lane freeway called the Vietnam Veterans Memorial Highway and reaches a trumpet interchange with the western terminus ofUS 22 Bus., which heads northeast into the borough ofLewistown. From here, the freeway crosses to the north side of Big Ridge as it bypasses Lewistown to the northwest, reaching adirectional T interchange with theUS 322 freeway. At this point, US 22/US 522 become concurrent with US 322 and the freeway has an interchange with Electric Avenue. From here, the freeway enters the borough of Lewistown and runs to the west of theKishacoquillas Creek. US 522 splits from US 22/US 322 at an interchange by heading northeast on East Walnut Street. At the US 522 interchange, the freeway passes over aJuniata Valley Railroad line. Past this interchange, US 22/US 322 curves south along the eastern border of Lewistown and crosses a Juniata Valley Railroad line at-grade before reaching an eastbound exit and westbound entrance with East Charles Street. The freeway crosses the Kishacoquillas Creek and leaves Lewistown upon crossingJacks Creek and heading into rural areas. The two routes curve east and come to a westbound exit and eastbound entrance with the eastern terminus of US 22 Bus., at which point the freeway begins to run along the north bank of the Juniata River, while the Pittsburgh Line runs on the south bank. US 22/US 322 curves to the northeast and runs between Shade Mountain to the north and the river to the south as it heads through the Lewistown Narrowswater gap.[4][5] This section of road includes the longestmechanically stabilized earth wall in the U.S.[6]
US 22/US 322 entersJuniata County and continues through the water gap, coming to an eastbound access point to a fishing and boating area along the Juniata River. Farther east, the freeway curves to the southeast and exits the Lewistown Narrows, heading further from the river and coming to a diamond interchange with Arch Rock Road. The two routes head northeast and then southeast, crossingLost Creek before turning south and reaching a diamond interchange withPA 35 east of the borough ofMifflintown. US 22/US 322 comes to a partial cloverleaf interchange with the northern terminus ofPA 75 northeast of the borough ofPort Royal. The freeway continues southeast, turning to the east-northeast. Farther east, the two routes come to a partial cloverleaf interchange withPA 333 on the northern border of the borough ofThompsontown. Past Thompsontown, US 22/US 322 has a westbound exit and eastbound entrance with Pfoutz Valley Road. After this interchange, the freeway runs closely parallel to the north bank of the Juniata River as it passes through a water gap inTuscarora Mountain.[4][5]
US 22/US 322 crosses intoPerry County, where the freeway and the parallel Juniata River turn southeast out of the water gap. The freeway enters the borough ofMillerstown and runs between the river to the west and the borough to the east, passing overPA 17. After leaving the borough, the two routes come to an interchange with West Juniata Parkway that provides access to PA 17 and Millerstown. US 22/US 322 continues through rural areas further east from the Juniata River. The freeway curves south as it passes west of Buffalo Mountain, making a turn east away from the river and reaching a diamond interchange withPA 34 northeast of the borough ofNewport. Past this interchange, the two routes begin to parallel the Juniata River again, turning southeast and then east. US 22/US 322 reaches a westbound exit and eastbound entrance with Meadow Grove Road that provides access toMidway and curves southeast alongside the river. The freeway continues south-southeast and reaches an interchange with Huggins Road that servesWatts; this interchange consists of a left exit and entrance eastbound and a right exit and entrance westbound. The two routes continue south parallel to the Juniata River and reach an interchange connecting to River Road that servesAmity Hall.[4][5]
US 22/US 322 entersDauphin County and comes to a modified cloverleaf interchange with theUS 11/US 15 freeway. Past this interchange, the freeway ends and the roadway becomes Benvenue Road, a four-lane divided highway. The two routes run through a mix of rural areas and businesses on Duncan Island between the Juniata River to the west and theSusquehanna River to the east. US 22/US 322 intersects the eastern terminus ofPA 849 east of the borough ofDuncannon, where the road becomes a freeway again. At this point, the unnamed freeway crosses the Susquehanna River on theClarks Ferry Bridge, which also carries theAppalachian Trail. After crossing the river, the two routes come to a directional T interchange with the southern terminus ofPA 147, where the Appalachian Trail splits to the south. Following this interchange, US 22/US 322 turns southwest and runs between the Susquehanna River to the northwest and Norfolk Southern'sBuffalo Line to the southeast. The freeway curves southeast along with the parallel river and railroad tracks as it passes west ofPeters Mountain. The two routes pass over the Norfolk Southern line and come to a diamond interchange withPA 325 inSpeeceville.
Past this interchange, US 22/US 322 heads east-southeast through rural areas to the north of the Susquehanna River and Norfolk Southern Railway's Buffalo Line, curving to the east. The freeway reaches a directional T interchange with the southern terminus ofPA 225 that serves the borough ofDauphin. From here, the two routes turn southeast and enter the borough of Dauphin, passing near developed areas. The freeway crossesStony Creek before coming to a westbound exit providing access to Allegheny Street and heading under the railroad line. US 22/US 322 leaves Dauphin and heads southeast between the Susquehanna River to the west and the Norfolk Southern Railway line to the east as it passes west of Second Mountain. Past the mountain, the freeway runs near developed areas farther from the river and comes to a partial cloverleaf interchange withPA 443 inFort Hunter. The two routes continue south-southeast, crossing over Norfolk Southern Railway's Buffalo Line and passing to the west ofBlue Mountain. US 22/US 322 heads southeast parallel to Norfolk Southern Railway's Pittsburgh Line to the west and reaches a diamond interchange withPA 39, where the parallel railroad line heads further west from the road. At this point, the freeway entersHarrisburg and runs betweenWildwood Park to the west and developed areas to the east, curving south and crossingPaxton Creek before coming to astack interchange withI-81. At this point, US 322 splits from US 22 by heading east concurrent with I-81.[4][5]
Past this interchange, US 22 continues south along the six-lane freeway along the eastern border of Harrisburg, passing to the east of theHarrisburg Area Community College campus. The freeway ends and the route becomes North Cameron Street, a four-lane divided highway with at-grade intersections that heads to the east of thePennsylvania Farm Show Complex & Expo Center. US 22 turns southeast onto four-lane divided Arsenal Boulevard, withPA 230 continuing south (east) along North Cameron Street towardDowntown Harrisburg. The road winds southeast through developed areas as it skirts along the northeast border of Harrisburg, narrowing to a three-lane road with one eastbound lane and two westbound lanes before turning into a three-lane road with a center left-turn lane. US 22 turns east-northeast onto two-lane undivided Herr Street and leaves Harrisburg, continuing through suburban areas and entering the borough ofPenbrook. Here, the route makes a turn northeast onto four-lane divided Walnut Street, leaving Penbrook and coming to an intersection withProgress Avenue. The road continues through suburban development inProgress, where it becomes a divided highway. The name of US 22 changes to Jonestown Road before it comes to a partial cloverleaf interchange withI-83/US 322. Following this interchange, the route heads intoColonial Park and runs through commercial areas, passing to the south ofColonial Park Mall. The road turns to the north-northeast and comes toPaxtonia, where it becomes Allentown Boulevard and reaches an intersection with Mountain Road, which provides access to I-81 a short distance to the north. From here, US 22 curves more to the east-northeast and continues through developed areas with some rural land and crossingBeaver Creek. Farther east, the route passes throughSkyline View and comes to an intersection with PA 39. Past this intersection, the road heads northeast through rural areas with some development, crossingManada Creek. NearGrantville, US 22 reaches a junction with the northern terminus ofPA 743 and Bow Creek Road, which heads north to an interchange with I-81.[4][5]
US 22 entersLebanon County and continues northeast through agricultural areas of theLebanon Valley along four-lane divided Allentown Boulevard. The route comes to a partial cloverleaf interchange withPA 934 north ofHarper Tavern and curves to the east. The road continues through rural areas with some development, passing north ofOno and turning to the east-northeast. US 22 reaches a cloverleaf interchange withPA 72 and crosses theSwatara Creek before it becomes William Penn Highway and passes to the north of the borough ofJonestown, heading between rural land to the north and developed areas to the south. The route continues through agricultural land, passing to the south ofNorthern Lebanon High School before coming to an intersection withPA 343 south ofFredericksburg. At this point, PA 343 turns east to join US 22 in a concurrency, with the road passing near warehouses. PA 343 splits from US 22 to head north to a partial interchange withI-78 that provides access to westbound I-78 and from eastbound I-78. Following this, US 22 continues east-northeast through development and rural land a short distance to the south of I-78. Farther east, the route splits from William Penn Highway and merges onto I-78 at a partial interchange, with access from eastbound US 22 to eastbound I-78 and from westbound I-78 to westbound US 22. The two routes continue east-northeast along a four-lane freeway.[4][5]
_just_east_of_Exit_23_in_Upper_Bern_Township%2c_Berks_County%2c_Pennsylvania.jpg)
I-78/US 22 entersBerks County and heads east-northeast through rural areas to the south of the Blue Mountain ridge, coming to adiamond interchange withPA 645 north ofFrystown. The road continues near some warehouses and reaches a diamond interchange withPA 501 north ofBethel. The freeway passes to the south ofGrimes Airport and coming to aright-in/right-out interchange with Court Street eastbound and Frantz Road westbound; this interchange has no access across the freeway. I-78/US 22 soon reaches a diamond interchange with Midway Road as it passes through more rural land, coming to a diamond interchange withPA 419 south ofSchubert. Past this interchange, the road crosses theLittle Swatara Creek. The freeway reaches a diamond interchange withPA 183 north ofStrausstown. I-78/US 22 crossesNorthkill Creek and comes to a diamond interchange with Mountain Road north ofShartlesville.[4][5] At this point, I-78/US 22 becomes the CMSgt. Richard L. Etchberger Memorial Highway, in honor ofRichard Etchberger.[7] Following this interchange, the road heads northeast through more rural areas, reaching a partial cloverleaf interchange withPA 61 in a business area that includes a 250,000-square-foot (23,000 m2)Cabela's store. Past PA 61, I-78/US 22 comes to a bridge over theReading Blue Mountain and Northern Railroad'sReading Division line and theSchuylkill River. Upon crossing the river, I-78/US 22 enters the borough ofHamburg and passes through residential areas, coming to a diamond interchange at North 4th Street that serves Hamburg. The road leaves Hamburg and heads through rural areas, curving to the east. Farther east, the parallel Blue Mountain ridge heads further north from the freeway. I-78/US 22 comes to a partial cloverleaf interchange withPA 143 north of the borough ofLenhartsville. The CMSgt. Richard L. Etchberger Memorial Highway name for I-78/US 22 ends at this interchange. Past this interchange, the road crossesMaiden Creek. Farther east, the freeway reaches a diamond interchange withPA 737 south ofKrumsville. The road continues east through rural land with some nearby development.[4][5]
I-78/US 22 entersLehigh County, where it becomes the Walter J. Dealtrey Memorial Highway[8] and continues east into theLehigh Valley, passing north ofNew Smithville. The road passes south of warehouses and comes to a diamond interchange withPA 863. Following this interchange, the freeway heads to the south of more warehouses and runs through more rural areas. I-78/US 22 runs between farm fields to the north and warehouses and industrial development to the south before it comes to a cloverleaf interchange withPA 100 inFogelsville. After the PA 100 interchange, the freeway widens to six lanes and heads east through industrial areas, coming to a bridge over Norfolk Southern Railway'sC&F Secondary railroad line before curving northeast. InKuhnsville, US 22 splits from I-78 at an eastbound exit and westbound entrance by heading northeast on a four-lane freeway named theLehigh Valley Thruway.[4][5]
_at_the_exit_for_Pennsylvania_State_Route_378_SOUTH_(Bethlehem%2c_Schoenersville_Road)_in_Bethlehem%2c_Lehigh_County%2c_Pennsylvania.jpg)
Upon splitting from I-78, US 22 runs east-northeast through developed areas and comes to a partial interchange withTilghman Street that serves the communities ofCetronia and Kuhnsville. A short distance later, the freeway reaches the Lehigh Valley interchange withI-476 (Pennsylvania Turnpike Northeast Extension), which is a double trumpet interchange. US 22 continues past I-476 to a cloverleaf interchange with thePA 309 freeway. Past the PA 309 interchange, the route runs near suburban neighborhoods as it passes to the north ofAllentown.
The freeway reaches a partial cloverleaf interchange withCedar Crest Boulevard and continues east-northeast to another partial cloverleaf interchange at 15th Street. US 22 heads intoWhitehall and passes overJordan Creek before it reaches a partial cloverleaf interchange withPA 145 in a business area, withLehigh Valley Mall located northeast of the interchange. The freeway runs past more suburban development and comes to a partial cloverleaf interchange with Fullerton Avenue inFullerton. Past this interchange, the route passes over theLehigh River and Norfolk Southern Railway'sLehigh Line on a bridge. US 22 continues east-northeast near development and reaches a cloverleaf interchange with the southern terminus ofPA 987 at Airport Road that servesLehigh Valley International Airport to the north. Following this interchange, the freeway entersBethlehem and comes to a trumpet interchange with the northern terminus of thePA 378 freeway before reaching a partial cloverleaf interchange with Schoenersville Road.[4][5]
At this interchange, US 22 leaves Bethlehem and entersNorthampton County, running northeast through suburban development. The route reaches a partial cloverleaf interchange with the southern terminus ofPA 512 and heads to the south of warehouses as it passes to the north of Bethlehem. The freeway passes over Norfolk Southern Railway's Cement Secondary railroad line and theMonocacy Creek before meeting the southern terminus ofPA 191 at a partial cloverleaf interchange. Past this interchange, US 22 continues east through a mix of suburban development and farmland before it comes to a cloverleaf interchange with thePA 33 freeway. The freeway heads through developed areas and reaches a partial cloverleaf interchange withPA 248, where it turns northeast and runs along the northern border of the borough ofWilson. The route curves east and fully enters Wilson before it crosses intoEaston and meets 13th Street at a partial cloverleaf interchange. After this interchange, US 22 winds east through a series of curves to the north of a cemetery, making a sharp turn to the southwest and crossingBushkill Creek before it turns sharply to the east. The route becomes an elevated highway that passes through developed areas to the north of downtown Easton, coming to a eastbound exit and westbound entrance with 4th Street and a westbound exit and eastbound entrance with 3rd Street and Snyder Avenue. US 22 has a westbound exit and eastbound entrance withPA 611 before it crosses theDelaware River on theEaston–Phillipsburg Toll Bridge intoNew Jersey.[4][5]
_from_the_overpass_for_Pennsylvania_State_Route_145_(MacArthur_Road)_in_Whitehall_Township%2c_Lehigh_County%2c_Pennsylvania.jpg)
TheWilliam Penn Highway was organized as an alternative to theLincoln Highway being parallel to thePennsylvania Railroad west of Harrisburg. The route'sNew York City extension was adopted in 1916. ThePennsylvania Department of Highways assigned thePA 3 designation to this road in 1924, and, in 1926, it became part of US 22 when theU.S. Numbered Highway System was formed.[9]
.svg) Pennsylvania Route 43 | |
|---|---|
| Location | Harrisburg–Bethlehem |
| Length | 87.41 mi[10] (140.67 km) |
| Existed | 1927–1946 |
The first alignment of the William Penn Highway became problematic for motorists inLebanon along the currentUS 422;Reading via US 22 andUS 222 andAllentown onHamilton Street, present-dayPA 222.[11] The highway continued through Allentown on Hanover Avenue and through Bethlehem on Broad Street, Linden Street, and Easton Avenue.
PA 43 was aligned as a bypass, north of thePennsylvania Dutch Country, that ran from US 22,US 11, andPA 5 inHarrisburg east toPA 12 inBethlehem.[12] From Harrisburg, this route followed modern-day US 22 to Paxtonia, then Jonestown Road to Jonestown and modern-day Old Route 22, Airport Road, and Main Street through Fredericksburg. East of here toFogelsville, the route is variously called Old Route 22, Shartlesville Road, and Hex Highway. The route from Fogelsville to the Allentown line, now Main Street and Tilghman Street, was designated Legislative Route 443 in 1925[13] before being incorporated into this route.[14] The route entered Harrisburg by Liberty Street and connected with the William Penn Highway through 17th Street.The New York Times was recommending use of this cutoff by early 1931.[14] On June 8, 1931, theAmerican Association of State Highway Officials came to a resolution for the traffic problem, by replacing the PA 43 corridor with US 22. ThePennsylvania Department of Highways moved the William Penn Highway name to match.[9][11] The state deleted a concurrency with PA 43 and what was thenUS 309 and truncated PA 43 to Susquehanna Street and Broadway from Allentown to Bethlehem.[15] Signs were changed to reflect the new designations on May 31, 1932, with the new route designations officially in place on June 1, 1932.[16]
Tilghman Street was eventually connected directly fromCetronia to Allentown by a bridge over Cedar Creek; Tilghman Street (west of the Lehigh River) and Union Boulevard (east of the river) were joined in 1929 by a bridge. By 1936, US 22 had been moved from its Hamilton and Broad streets alignment to Tilghman Street and Union Boulevard through Allentown and Bethlehem. From Bethlehem to Easton, an alternate route was formed along Goepp Street, Pembroke Road, and Freemansburg Avenue. With the construction ofa new bridge over the Delaware River in 1938, Prospect Avenue, Pearl Street, and Snyder Street in Easton were incorporated into US 22.[17] A new alignment from Fredericksburg to Paxtonia was built in the early 1940s. When the Lehigh Valley Thruway was completed in 1954, US 22 was moved onto it; its old alignment was redesignatedState Route 1002 (SR 1002) through Lehigh County. With the completion ofI-78, US 22 was moved onto that highway from Fredericksburg to Kuhnsville. The former alignment, although no longer a major state highway, is still well traveled by those who live in the vicinity.[citation needed]
I-78 originally would have continued with the US 22 concurrency on the Lehigh Valley Thruway intoNew Jersey, andI-178 andI-378, serving Allentown and Bethlehem, respectively. Due to opposition inPhillipsburg, New Jersey, on the building of a new highway through the town, thePennsylvania andNew Jersey departments of transportation decided to reroute I-78 to the south and allow US 22 to remain on the limited-access highway, which, after going through a series of sharp, potentially dangerous curves in Easton and crossing theDelaware River into New Jersey, becomes an at-grade divided highway in Phillipsburg.
The origins of this section of US 22 date back to the early 1800s, with the chartering of the Harrisburg, Lewistown, Huntingdon, and Pittsburgh Turnpike in 1807, following the course of what would become US 22 from Harrisburg to Pittsburgh,[18] providing a more northerly alternative to theHarrisburg and Pittsburgh Turnpike chartered the year prior. Support for the turnpike was lacking along its route, and so, to foster a sense of locality to the road, the company was broken up in the subsequent years into five sections: the Huntingdon, Cambria, and Indiana in 1810 (terminating at Huntingdon and Blairsville); the New Alexandria and Conemaugh in 1816 (Blairsville to New Alexandria); the Pittsburgh and New Alexandria Turnpike in 1816; and the Harrisburg and Millerstown, Millerstown and Lewistown, and Lewistown and Huntingdon turnpikes in 1821. In their own times, these companies constructed a highway across the Appalachian Mountains collectively called the Northern Pike, but all folded with competition from theMain Line of Public Works and, later, thePennsylvania Railroad.[citation needed]
In its earliest years, US 22 deviated from the original course of the William Penn Highway in a few notable places. With the construction of the Boulevard of the Allies in the early 1920s, the highway was rerouted to service this thoroughfare. This alignment entered Pittsburgh on modern day PA 8, then made its way downtown by Dallas Avenue, Wilkins Avenue, Beeler Street, Forbes Street, theBoulevard of the Allies, and Second Street. The highway then followed the old Pittsburgh and Steubenville Pike to Ohio. With the construction of the Penn-Lincoln Parkway in the late 1950s, both US 22 and US 30 were shifted to the new highway.
Further east, where the William Penn Highway deviated from the Northern Pike betweenEbensburg andWater Street to serviceAltoona andTyrone, the Northern Pike was restored as the main east–west thoroughfare, whileUS 220 was chosen to service these cities. A few notable deviations from this include Turkey Valley Road near Canoe Creek Lake, and a bend servicingWilliamsburg via modern-dayPA 866 and SR 2015, which both deviated from the Northern Pike.[19] These were later christened as PA 303 and PA 203 respectively when the highway was restored to the Northern Pike.[12] Near theSusquehanna River, before an alignment along theJuniata River had been constructed, the highway servicedNew Bloomfield and Meck's Corner by modern-dayPA 34 andPA 274; while US 22 was shifted north, this alignment still held its old designation of PA 3 for some time afterward.[12]
In 2011, it was announced that plans were being resurrected to widen US 22 fromAllentown toBethlehem. Part of the plan is to reconstruct the Lehigh River Bridge. The plan's cost is between $240 million to $320 million.[20] In late 2019, plans to study a potential upgrade to an interstate were announced since additional federal funding is available for interstate construction.[citation needed]
| This sectiondoes notcite anysources. Please helpimprove this section byadding citations to reliable sources. Unsourced material may be challenged andremoved.(October 2022) (Learn how and when to remove this message) |
 | This section ismissing mileposts for junctions. Please help byadding them. |
| County | Location | mi | km | Exit | Destinations | Notes |
|---|---|---|---|---|---|---|
| Washington | Hanover Township | 0.00 | 0.00 |  US 22 west –Weirton | Continuation intoWest Virginia | |
| 5.3 | 8.5 |  PA 18 –Florence,Burgettstown | Access toRaccoon Creek State Park andThe Pavilion at Star Lake | |||
| Robinson Township | 9.7 | 15.6 | Bavington | Access via Maple Grove Road | ||
| 11.4 | 18.3 |     PA Turnpike 576 toI-79 –Pittsburgh International Airport,Washington | PA 576 exit 6 | |||
| Allegheny | North Fayette Township | 12.8 | 20.6 |   PA 980 south –McDonald,Midway | Northern terminus of PA 980 | |
| 14.4 | 23.2 | Noblestown | Access via Kelso Road; access to Pennsylvania Motor Speedway | |||
| 16.0 | 25.7 |   US 30 west /PA 978 south –Imperial | Western terminus of US 30 concurrency; northern terminus of PA 978; access toRaccoon Creek State Park | |||
| 17.4 | 28.0 | Hankey Farms | Access via Oakdale Road | |||
| 18.4 | 29.6 |  Orange Belt (Oakdale) | Westbound exit and eastbound entrance; western terminus of Orange Belt concurrency | |||
| 19.5 | 31.4 | Montour Church Road / Old Steubenville Pike / Bayer Road | Westbound exit and eastbound entrance | |||
| Robinson Township | 19.9– 20.4 | 32.0– 32.8 | 60 |    I-376 west /Orange Belt /PA 60 south –Airport,Crafton | Signed as exits 60A (west) and 60B (south); eastern terminus of Orange Belt concurrency; western terminus of I-376 concurrency; exit number not signed eastbound | |
| 20.7 | 33.3 | 61 | Ridge Road | |||
| Robinson–Collier township line | 21.9 | 35.2 | 62 |  Yellow Belt (Campbells Run Road) | Westbound exit and eastbound entrance | |
| Robinson Township | 23.5 | 37.8 | 64A | I-79 –Washington,Erie | I-79 exit 59 | |
| Rosslyn Farms | 24.3 | 39.1 | 64B | Rosslyn Farms | Westbound exit and eastbound entrance; access via Rosslyn Road | |
| Carnegie | 24.8 | 39.9 | Buses only (West Busway) | Eastbound exit and westbound entrance | ||
| 25.2 | 40.6 | 65 |  PA 50 –Carnegie,Heidelberg | |||
| Green Tree | 27.0 | 43.5 | 67 |  PA 121 –Green Tree,Mount Lebanon,Crafton | ||
| Pittsburgh | 27.6 | 44.4 | 68 | Parkway Center Drive | Westbound exit and eastbound entrance | |
| 28.2 | 45.4 | 69A |  US 19 south (Banksville Road) | Western terminus of US 19/US 19 Truck concurrency; eastbound exit is via exit 69C | ||
| 28.7 | 46.2 | 69B |   US 19 Truck south /PA 51 south –Uniontown | Westbound exit is via exit 69A | ||
| 28.7 | 46.2 | 69C |  US 19 north /PA 51 north –West End | Eastern terminus of US 19 concurrency; eastbound exit and westbound entrance | ||
| 29.1 | 46.8 | Fort Pitt Tunnel underMount Washington | ||||
| 29.6 | 47.6 | 69C |   PA 837 toPA 51 –West End | Westbound exit and eastbound entrance | ||
| Monongahela River | 29.7 | 47.8 | Fort Pitt Bridge | |||
| Pittsburgh | 29.7 | 47.8 | 70A | Boulevard of the Allies /Liberty Avenue –PPG Arena | Eastbound exit and westbound entrance | |
| 29.7 | 47.8 | 70B | Fort Duquesne Boulevard –Convention Center,Strip District | Eastbound exit and westbound entrance | ||
| 29.7 | 47.8 | 70C |   I-279 north (US 19 Truck north) –Fort Duquesne Bridge,North Shore | Eastern terminus of US 19 Truck concurrency | ||
| 30.0 | 48.3 | 70D | Stanwix Street | No eastbound exit | ||
| 30.4 | 48.9 | 71A | Grant Street | |||
| 30.9 | 49.7 | 71B | Second Avenue | Westbound exit only | ||
| 31.8 | 51.2 | 72A | Forbes Avenue –Oakland | Eastbound exit and westbound entrance | ||
| 32.1 | 51.7 | 72B |  Boulevard of the Allies (PA 885 north) toI-579 north –Liberty Bridge | No eastbound exit; eastbound left entrance | ||
| 32.6 | 52.5 | 73 |  PA 885 (Bates Street) –Oakland,Glenwood | Westbound exit and eastbound entrance; signed as exits 73A (south) and 73B (north) | ||
| 34.2 | 55.0 | 74 |  Blue Belt –Squirrel Hill,Homestead | |||
| 34.8 | 56.0 | Squirrel Hill Tunnel underSquirrel Hill | ||||
| Pittsburgh–Swissvale– Edgewood tripoint | 36.4 | 58.6 | 77 | Edgewood,Swissvale | Access via Braddock Avenue | |
| Wilkinsburg | 37.7 | 60.7 | 78A |  US 30 east –Forest Hills | Eastern terminus of US 30 concurrency; no westbound exit | |
| 37.9 | 61.0 | 78B |  PA 8 north –Wilkinsburg | Southern terminus of PA 8 | ||
| Churchill | 38.6 | 62.1 | 79A | Greensburg Pike | Eastbound exit and westbound entrance | |
| 39.1 | 62.9 | 79B |  PA 130 –Churchill | |||
| 39.9 | 64.2 | 80 |  US 22 Bus. east –Monroeville | Eastbound exit and westbound entrance | ||
| 40.2 | 64.7 | 81 |  PA 791 north /Yellow Belt –Penn Hills | |||
| Monroeville | 43.8– 44.0 | 70.5– 70.8 | 84 |  US 22 Bus. west /PA 48 south /Orange Belt –Monroeville,Plum | Eastbound exit and westbound entrance; signed as exits 84A (south) and 84B (north); US 22 Bus. not signed | |
| 44.5 | 71.6 | 85 |    I-76 Toll /Penna Turnpike /US 22 Bus. west –Monroeville,Ohio,Harrisburg I-376 ends | Eastern terminus of I-376; exit number not signed westbound; no eastbound access to US 22 Bus. | ||
| Eastern end of freeway section | ||||||
| 46.4 | 74.7 |  PA 286 east (Golden Mile Highway) | Eastbound exit and westbound entrance, westbound exit and eastbound entrance provided by at-grade intersection; western terminus of PA 286 | |||
| Westmoreland | Salem Township | 54.8 | 88.2 |     PA 66 toPA Turnpike 66 south –Delmont,Greensburg | Single-point urban interchange | |
| 57.4 | 92.4 |  PA 819 –Slickville,Forbes Road,Greensburg | ||||
| 61.8 | 99.5 |  US 119 south –Greensburg | Western terminus of US 119 concurrency | |||
| New Alexandria–Derry Township line | 62.8 | 101.1 |  PA 981 (Latrobe New Alexandria Road) –Latrobe,Saltsburg | |||
| Derry Township | 67.3 | 108.3 |  PA 982 south –Derry | Northern terminus of PA 982 | ||
| Indiana | Blairsville | 71.5 | 115.1 |  PA 217 –Blairsville,Derry | Interchange | |
| Burrell Township | 74.2 | 119.4 | US 119 north –Homer City,Indiana | Interchange; eastern terminus of US 119 concurrency; access toIndiana University of Pennsylvania | ||
| West Wheatfield Township | 80.3 | 129.2 |  PA 259 –Brush Valley,Robinson,Bolivar | Interchange | ||
| East Wheatfield Township | Western end of freeway section | |||||
| 84.4 | 135.8 |  PA 56 –Brush Valley,Armagh | Access toJohnstown | |||
| East Philadelphia Street | Eastbound exit and entrance | |||||
| 85.6 | 137.8 |  PA 403 –Dilltown,Johnstown | ||||
| Eastern end of freeway section | ||||||
| Cambria | Jackson Township | Dishong Mountain Road | Interchange | |||
| 95.2 | 153.2 |  PA 271 –Mundys Corner,Nanty Glo | Interchange | |||
| Cambria Township | 99.5 | 160.1 |   US 219 toUS 422 –Johnstown,Carrolltown,Indiana | Interchange | ||
| 100.9 | 162.4 | Ebensburg | Interchange; no westbound exit; access via High Street | |||
| 102.8 | 165.4 | Western end of freeway section | ||||
| 102.8 | 165.4 | Ebensburg,Loretto | Access via Rowena Drive/Admiral Peary Highway | |||
| Munster Township | 105.9 | 170.4 |  PA 164 south –Munster,Portage | Northern terminus of PA 164 | ||
| Cresson Township | 109.0 | 175.4 |  PA 53 –Cresson,Lilly,Portage | Cresson signed eastbound; Portage signed westbound; access toMount Aloysius College andPrince Gallitzin State Park | ||
| 111.1 | 178.8 | Cresson,Summit | Access via Admiral Peary Highway; Cresson signed westbound; access toMount Aloysius College andPrince Gallitzin State Park | |||
| Cambria–Blair county line | Cresson–Allegheny township line | 112.8 | 181.5 | Gallitzin | Access via Tunnelhill Road; access toAllegheny Portage Railroad National Historic Site | |
| Blair | Allegheny Township | 119.2 | 191.8 |   I-99 /US 220 –Altoona,Bedford | I-99/US 220 exit 28 | |
| 120.2 | 193.4 |  PA 764 north –Altoona | Southern terminus of PA 764 | |||
| 120.2 | 193.4 | Eastern end of freeway section | ||||
| 121.8 | 196.0 |  US 220 Bus. south (Old US 220) toI-99 south /US 220 south –Newry,Bedford | Western terminus of US 220 Bus. concurrency | |||
| Blair Township | US 220 Bus. north (Plank Road) toI-99 /US 220 –Altoona | Eastern terminus of US 220 Bus. concurrency | ||||
| Hollidaysburg | 124.6 | 200.5 |  PA 36 (Penn Street) –Altoona,Roaring Spring | |||
| Frankstown Township | 136.3 | 219.4 |  PA 866 south (Juniata River Road) –Williamsburg | Northern terminus of PA 866 | ||
| Huntingdon | Morris Township | 142.0 | 228.5 |   PA 453 north (Birmingham Pike) toPA 45 –Tyrone,State College | Southern terminus of PA 453 | |
| Porter Township | 144.6 | 232.7 |  PA 305 east (Bridge Street) –Alexandria | Western terminus of PA 305 | ||
| Smithfield Township | 150.2 | 241.7 |  PA 26 –Everett,Huntingdon,State College | Interchange | ||
| Fairgrounds Road | Interchange | |||||
| Henderson Township | ToPA 26 north –Huntingdon,State College | Interchange; access via Penn Street | ||||
| 156.4 | 251.7 |  PA 829 south –Cassville | Northern terminus of PA 829 | |||
| Mill Creek | 157.2 | 253.0 |  PA 655 north –Belleville | Western terminus of PA 655 concurrency | ||
| Brady Township | 158.6 | 255.2 | PA 655 south (Oriskany Road) –Mapleton,Saltillo | Eastern terminus of PA 655 concurrency | ||
| Mifflin | Wayne Township | 163.1 | 262.5 |  PA 747 south (North Jefferson Street) –Mount Union | Northern terminus of PA 747 | |
| 163.5 | 263.1 |  US 522 south (Croghan Pike) –Orbisonia | Western terminus of US 522 concuurency | |||
| Granville Township | 182.2 | 293.2 | Western end of freeway section | |||
| 182.2 | 293.2 | US 22 Bus. east | Western terminus of US 22 Bus. | |||
| Derry Township | 186.2 | 299.7 |  US 322 west –State College | Western terminus of US 322 concurrency | ||
| 186.4 | 300.0 | Electric Avenue | ||||
| Lewistown | 187.0 | 300.9 | US 522 north (Walnut Street) –Selinsgrove | Eastern terminus of US 522 concurrency | ||
| Derry Township | 187.4 | 301.6 | East Charles Street | Eastbound exit and westbound entrance | ||
| 189.3 | 304.6 | US 22 Bus. west –Lewistown | Westbound exit and eastbound entrance; eastern terminus of US 22 Bus. | |||
| Juniata | Fermanagh Township | Fishing/Boating Access Area | Eastbound exit and entrance | |||
| 196.9 | 316.9 | Arch Rock Road | Access toMifflintown Airport | |||
| 200.1 | 322.0 |  PA 35 –McAlisterville,Mifflintown | ||||
| Walker Township | 202.0 | 325.1 |  PA 75 south –Port Royal | Northern terminus of PA 75 | ||
| Delaware Township–Thompsontown line | 209.6 | 337.3 |  PA 333 –East Salem,Thompsontown | |||
| Delaware Township | 211.2 | 339.9 | Pfoutz Valley Road | Westbound exit and eastbound entrance | ||
| Perry | Greenwood Township | 215.0 | 346.0 |  ToPA 17 –Millerstown | Access via West Juniata Parkway | |
| Howe Township | 219.5 | 353.3 |  PA 34 –Newport,New Bloomfield | Access toLittle Buffalo State Park | ||
| Buffalo Township | 223.3 | 359.4 | Midway | Westbound exit and eastbound entrance; access via Meadow Grove Road | ||
| Watts Township | 225.9 | 363.6 | Watts | Left exit eastbound; right exit westbound; access via Huggins Road | ||
| 227.8 | 366.6 | Amity Hall | Westbound exit and entrance; access via River Road | |||
| Dauphin | Reed Township | 228.0 | 366.9 |   US 11 /US 15 –Camp Hill,Selinsgrove,Williamsport | Williamsport signed westbound | |
| Eastern end of freeway section | ||||||
| 229.4 | 369.2 |  PA 849 west –Duncannon | Eastern terminus of PA 849; no access from PA 849 to US 22/US 322 westbound | |||
| Western end of freeway section | ||||||
| Susquehanna River | Clarks Ferry Bridge | |||||
| Reed Township | 229.8 | 369.8 |  PA 147 north –Halifax | Southern terminus of PA 147 | ||
| Middle Paxton Township | 231.8 | 373.0 |  PA 325 east (Mountain Road) | Western terminus of PA 325 | ||
| 235.2 | 378.5 |  PA 225 north –Halifax,Dauphin | Dauphin signed eastbound; southern terminus of PA 225 | |||
| Dauphin | 236.2 | 380.1 | Dauphin Boro,Stony Creek | Westbound exit; access via Allegheny Street | ||
| Middle Paxton Township | 237.6 | 382.4 |  PA 443 –Fishing Creek,Rockville | Rockville signed eastbound | ||
| Susquehanna Township–Harrisburg line | 239.5 | 385.4 |  PA 39 –Linglestown,Rockville | Rockville signed westbound | ||
| Harrisburg | 241.5 | 388.7 |     I-81 /US 322 east (Capital Beltway) toI-78 east /I-83 –Carlisle,Hershey,Hazleton,Allentown | I-81 exit 67; eastern terminus of US 322 concurrency; signed for I-83/Hershey eastbound, I-78/Hazleton westbound | ||
| Eastern end of freeway section | ||||||
 PA 230 east (Cameron Street) | Western terminus of PA 230 | |||||
| Lower Paxton Township | I-83 /US 322 (Capital Beltway) toI-81 –Carlisle,Hazleton,Hershey,York | I-83 exit 50 | ||||
| West Hanover Township | PA 39 (Hershey Road) toI-81 –Hershey | |||||
| East Hanover Township |  PA 743 south (Laudermilch Road) toI-81 –Grantville,Hershey | Northern terminus of PA 743 | ||||
| Lebanon | East Hanover Township |  PA 934 toI-81 –Annville,Fort Indiantown Gap | Interchange | |||
| Union Township |  PA 72 toI-81 –Lebanon,Lickdale | |||||
| Bethel Township |  PA 343 south (Pine Grove Street) –Lebanon | Western terminus of PA 343 concurrency | ||||
| PA 343 north (Pine Grove Road) toI-78 west | Eastern terminus of PA 343 concurrency | |||||
| Local Traffic | Old US 22 to Mount Zion Road | |||||
| Western end of freeway section | ||||||
| 8 | I-78 west –Harrisburg | Westbound exit and eastbound entrance; western terminus of I-78 concurrency | ||||
| Berks | Bethel Township | 10 |  PA 645 –Frystown | |||
| 13 |  PA 501 –Bethel | |||||
| 15 | Grimes | Right-in/right-out connections only; access via Court Street/Frantz Road; no tractor trailers | ||||
| 16 | Midway | Access via Midway Road | ||||
| 17 |  PA 419 –Rehrersburg | Access toConrad Weiser Homestead | ||||
| Upper Tulpehocken Township | 19 |  PA 183 –Strausstown | ||||
| Upper Bern Township | 23 | Shartlesville | Access via Mountain Road | |||
| Tilden Township | 29 |  PA 61 –Pottsville,Reading | ||||
| Hamburg | 30 | Hamburg | Access via North 4th Street | |||
| Greenwich Township | 35 |  PA 143 –Lenhartsville | ||||
| 40 |  PA 737 –Kutztown,Krumsville | Access toKutztown University of Pennsylvania | ||||
| Lehigh | Weisenberg Township | 45 |  PA 863 –Lynnport,New Smithville | |||
| Upper Macungie Township | 49 |  PA 100 –Trexlertown,Fogelsville | Signed as exits 49A (south) and 49B (north) | |||
| 51 | I-78 east –New Jersey | Eastbound exit and westbound entrance; eastern terminus of I-78 concurrency | ||||
| 315.7 | 508.1 | Cetronia,Kuhnsville | Access via SR 1002; signed for Cetronia eastbound, Kuhnsville westbound | |||
| South Whitehall Township | 316.1 | 508.7 |  I-476 Toll /Penna Turnpike NE Extension –Philadelphia,Scranton | I-476 / Turnpike exit 56; formerPA 9 | ||
| 316.7 | 509.7 |  PA 309 –Quakertown,Tamaqua | ToI-78 east; access toDorney Park, andLehigh Carbon Community College | |||
| 318.7 | 512.9 | Cedar Crest Boulevard (SR 1019) | Access toMuhlenberg College andCedar Crest College | |||
| 320.3 | 515.5 | 15th Street | Access via Mauch Chunk Road | |||
| Whitehall Township | 321.0 | 516.6 |  PA 145 (MacArthur Road / 7th Street) | Access toAllentown Center City | ||
| 322.1 | 518.4 | Fullerton Avenue | ||||
| Hanover Township–Bethlehem line | 324.0 | 521.4 | Airport Road south | |||
 PA 987 north (Airport Road) –Lehigh Valley International Airport | Southern terminus of PA 987 | |||||
| Bethlehem | 325.1 | 523.2 |  PA 378 south –Bethlehem | Northern terminus of PA 378; former I-378 | ||
| Northampton | 325.6 | 524.0 | Schoenersville Road | |||
| Hanover Township | 327.4 | 526.9 |  PA 512 north (Center Street) | Southern terminus of PA 512; access toMoravian University | ||
| Bethlehem Township | 329.9 | 530.9 |  PA 191 north (Nazareth Pike) | Southern terminus of PA 191 | ||
| 332.3 | 534.8 |   PA 33 toI-78 /I-80 –Stroudsburg | I-80 not signed eastbound; access to thePocono Mountains | |||
| Palmer Township | 334.5 | 538.3 |  PA 248 / 25th Street –Wilson | Access toPalmer | ||
| Easton | 336.0 | 540.7 | 13th Street | Access via Wood Avenue | ||
| 337.5 | 543.2 |  PA 248 / 4th Street toPA 611 | Eastbound exit and westbound entrance | |||
| 337.8 | 543.6 | Snyder Street –Easton,Lafayette College | Westbound exit only | |||
| 337.9 | 543.8 | PA 248 west /PA 611 –Easton | Westbound exit and eastbound entrance; PA 248 not signed | |||
| Delaware River | 338.20 | 544.28 | Easton–Phillipsburg Toll Bridge (westbound toll in New Jersey) | |||
| US 22 east toI-78 –Phillipsburg | Continuation intoNew Jersey | |||||
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi | ||||||
Here one meets and follows U.S. Route 22 through Bethlehem to Allentown; then along Route 43 direct to Harrisburg.
 U.S. Route 22 | ||
|---|---|---|
| Previous state: West Virginia | Pennsylvania | Next state: New Jersey |
