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Tyloxapol

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Pharmaceutical drug
Pharmaceutical compound
Tyloxapol
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  • formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
CAS Number
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ECHA InfoCard100.209.660Edit this at Wikidata
Chemical and physical data
Formula(C15H21O(C2H4O)m)n
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Tyloxapol is a nonionic liquidpolymer of the alkyl aryl polyether alcohol type. It is used as asurfactant to aidliquefaction and removal of mucopurulent[citation needed] (containingmucus andpus) bronchopulmonary secretions,[1][2] administered by inhalation through anebulizer[3] or with a stream of oxygen.

Withintraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown oftriglyceride-richlipoproteins. This mechanism is used to induce experimentalhyperlipidemia in animals.[4]

Tyloxapol is the main active ingredient of the medical device Tacholiquin. Tacholiquin is an expectorant designated for inhalation and instillation reaching the upper and lower airways.Other brand names of pharmaceutical products containing Tyloxapol are Exosurf and Alevaire.

References

[edit]
  1. ^Sehgal SS, Ewing CK, Richards T, Taeusch HW (January 1994)."Modified bovine surfactant (Survanta) versus a protein-free surfactant (Exosurf) in the treatment of respiratory distress syndrome in preterm infants: a pilot study".Journal of the National Medical Association.86 (1):46–52.PMC 2607653.PMID 8151722.
  2. ^Rubin BK, Ramirez O, King M (April 1992). "Mucus rheology and transport in neonatal respiratory distress syndrome and the effect of surfactant therapy".Chest.101 (4):1080–5.doi:10.1378/chest.101.4.1080.PMID 1555424.
  3. ^"Tyloxapol definition".Drugs.com.
  4. ^Kourounakis AP, Victoratos P, Peroulis N, Stefanou N, Yiangou M, Hadjipetrou L, Kourounakis PN (October 2002). "Experimental hyperlipidemia and the effect of NSAIDs".Experimental and Molecular Pathology.73 (2):135–8.doi:10.1006/exmp.2002.2449.PMID 12231215.
Expectorants
Mucolytics
Cough suppressants
Opium alkaloids,
opioids,
and derivatives
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