 | |
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Pregnancy category |
|
| Routes of administration | Oral (capsules, tablets, oral solution) |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | Variably absorbed from GI tract |
| Excretion | Primarily excreted unchanged in urine |
| Identifiers | |
| |
| CAS Number |
|
| PubChemCID | |
| IUPHAR/BPS | |
| DrugBank |
|
| ChemSpider |
|
| UNII | |
| KEGG |
|
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.004.654 |
| Chemical and physical data | |
| Formula | C8H8Cl3N3O4S2 |
| Molar mass | 380.64 g·mol−1 |
 N Y (what is this?) (verify) | |
Trichlormethiazide (INN, currently being sold under the brand names ofAchletin,Diu-Hydrin andTriflumen) is adiuretic with properties similar to those ofhydrochlorothiazide.[1] It is usually administered for the treatment ofoedema (including that which is associated withheart failure,hepatic cirrhosis andcorticosteroid therapy) andhypertension.[1] Inveterinary medicine, trichlormethiazide can be combined withdexamethasone to be used on horses with mild swelling ofdistal limbs and generalbruising.[2]
As a diuretic (in particular athiazide), trichlormethiazide encourages water loss from the body.[1] Trichlormethiazide works byinhibiting Na+/Cl− ion reabsorption from thedistaltubules of thekidneys.[1] In addition, trichlormethiazide increases theexcretion ofpotassium.[1]
Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic.[1] Although trichlormethiazide is used to treat hypertension, itshypotensive effects may not necessarily be due to its role as a diuretic.[1] Thiazides in general causevasodilation by activating calcium-activated potassium channels in vascular smooth muscles and inhibiting variouscarbonic anhydrases invascular tissue.[1]
