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Thiazinamium metilsulfate

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Chemical compound
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Pharmaceutical compound
Thiazinamium metilsulfate
Thiazinamium
Clinical data
ATC code
Identifiers
  • N,N,N-trimethyl-1-(10H-phenothiazin-10-yl)propan-2-aminium
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.017.320Edit this at Wikidata
Chemical and physical data
FormulaC18H23N2S+
Molar mass299.46 g·mol−1
3D model (JSmol)
  • CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)[N+](C)(C)C
  • InChI=1S/C18H23N2S.CH4O4S/c1-14(20(2,3)4)13-19-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)19;1-5-6(2,3)4/h5-12,14H,13H2,1-4H3;1H3,(H,2,3,4)/q+1;/p-1
  • Key:BVIDQAVCCRUFGU-UHFFFAOYSA-M
 ☒NcheckY (what is this?)  (verify)

Thiazinamium metilsulfate (INN) orthiazinam is anantihistamine. TheUSAN isthiazinamium chloride (with a differentcounterion).

Synthesis

[edit]

Since many of the uses of antihistamines involve conditions such as rashes, which should be treatable by local application, there is some rationale for developing drugs for topical use. The known side effects of antihistamines could in principle be avoided if the drug were functionalized to avoid systemic absorption. The known poor absorption ofquat salts make such derivatives attractive for nonabsorbable antihistamines for topical use.

Thiazinamium chloride synthesis frompromethazine andchloromethane.[1]

See also

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References

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  1. ^Lewis AJ, Dervinis A, Carlson RP, Rosenthale E, Daniel WC (1982)."Thiazinamium chloride: A bronchodilator with antiallergic activity in animals".Journal of Allergy and Clinical Immunology.69: 155.doi:10.1016/S0091-6749(62)80531-4.
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