| Ser/Thr protein kinase, TGFB receptor | |
|---|---|
| Identifiers | |
| Symbol | TGFb_receptor |
| InterPro | IPR000333 |
| SCOP2 | 1B6C /SCOPe /SUPFAM |
| Membranome | 1216 |
Thetransforming growth factor beta (TGFβ) receptors are afamily ofserine/threonine kinase receptors involved inTGF beta signaling pathway. These receptors bindgrowth factor andcytokinesignaling proteins in theTGF-beta family such asTGFβs (TGFβ1,TGFβ2,TGFβ3),bone morphogenetic proteins (BMPs),growth differentiation factors (GDFs),activin and inhibin,myostatin,anti-Müllerian hormone (AMH), andNODAL.[1]
TGFβ family receptors are grouped into three types, type I, type II, and type III. There are seven type I receptors, termed theactivin-like receptors (ALK1–7), five type II receptors, and one type III receptor, for a total of 13 TGFβ superfamily receptors.[2][3] In the transduction pathway, ligand-bound type II receptors activate type I receptors by phosphorylation, which then autophosphorylate and bind SMAD.[4] The Type I receptors have a glycine-serine (GS, or TTSGSGSG) repeat motif of around 30 AA, a target of type II activity. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.[5]
| Transforming growth factor beta type I GS-motif | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TGF_beta_GS | ||||||||
| Pfam | PF08515 | ||||||||
| InterPro | IPR003605 | ||||||||
| |||||||||
Unlike the Type I and II receptors which are kinases, TGFBR3 has aZona pellucida-like domain. Its core domain binds TGF-beta family ligands and its heparan sulfate chains bindbFGF. It acts as a reservoir of ligand for TGF-beta receptors.[6][7]
