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Stephen Oliver (scientist)

From Wikipedia, the free encyclopedia
For other people with the same name, seeStephen Oliver.

Steve Oliver
Born
Stephen George Oliver

(1949-11-03)3 November 1949 (age 75)[3]
Alma materUniversity of Bristol
Known for
Awards
Scientific career
Institutions
ThesisThe role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae. (1975)
Websitewww.bioc.cam.ac.uk/research/oliverEdit this at Wikidata

Stephen George OliverFMedSci (born 3 November 1949) is anEmeritusProfessor in the Department ofBiochemistry at theUniversity of Cambridge,[6][7] and aFellow ofWolfson College, Cambridge.[1][8]

Education

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Oliver was educated at theUniversity of Bristol gaining aBachelor of Science degree inMicrobiology in 1971 followed by aPhD from theNational Institute for Medical Research (NIMR) in 1974.[9]

Research

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Oliver's areas of research includefunctional genomics,systems biology[10][11][12] anddrug discovery[13][14][15][16][17][18] using themodel organismSaccharomyces cerevisiae[19] which he has worked on since the 1970s.[20] In 1992, whilst working atUMIST, Oliver led the team which provided first complete sequence analysis of an entire chromosome from any organism.[21] More recently he has also been involved in the creation of aRobot Scientist[5][22] and has been awarded research funding asprincipal investigator or co-investigator with a total value of over £26 million by theBiotechnology and Biological Sciences Research Council (BBSRC).[23]

References

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  1. ^ab"Professor Steve Oliver | Wolfson College Cambridge".Archived from the original on 8 August 2014.
  2. ^Cornell, M.; Paton, N. W.;Oliver, S. G. (2004)."A critical and Integrated View of the Yeast Interactome".Comparative and Functional Genomics.5 (5):382–402.doi:10.1002/cfg.412.PMC 2447467.PMID 18629175.
  3. ^abcAnon (2014)."Oliver, Prof. Stephen George".Who's Who (online edition viaOxford University Press ed.). A & C Black.doi:10.1093/ww/9780199540884.013.U247362.(Subscription orUK public library membership required.)
  4. ^Oliver, S. (1977). "On the mutability of the yeast mitochondrial genome".Journal of Theoretical Biology.67 (2):195–201.Bibcode:1977JThBi..67..195O.doi:10.1016/0022-5193(77)90193-X.PMID 330960.
  5. ^abKing, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.;Muggleton, S. H.;Kell, D. B.;Oliver, S. G. (2004)."Functional genomic hypothesis generation and experimentation by a robot scientist".Nature.427 (6971):247–252.Bibcode:2004Natur.427..247K.doi:10.1038/nature02236.PMID 14724639.S2CID 4428725.
  6. ^Stephen Oliver publications fromEurope PubMed CentralEdit this at Wikidata
  7. ^"Steve Oliver – Cambridge Systems Biology Centre". 5 November 2012.Archived from the original on 14 January 2013.
  8. ^Stephen Oliver's publications indexed by theScopus bibliographic database.(subscription required)
  9. ^Oliver, Stephen (1975).The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae (PhD thesis). Council for National Academic Awards.ProQuest 301313077.
  10. ^Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.;Oliver, S.; Fields, S.;Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions".Nature.417 (6887):399–403.Bibcode:2002Natur.417..399V.doi:10.1038/nature750.PMID 12000970.S2CID 4419762.
  11. ^Goffeau, A.; Barrell, B. G.; Bussey, H.; Davis, R. W.; Dujon, B.; Feldmann, H.; Galibert, F.; Hoheisel, J. D.; Jacq, C.; Johnston, M.; Louis, E. J.; Mewes, H. W.; Murakami, Y.; Philippsen, P.; Tettelin, H.; Oliver, S. G. (1996). "Life with 6000 Genes".Science.274 (5287): 546,563–7.Bibcode:1996Sci...274..546G.doi:10.1126/science.274.5287.546.PMID 8849441.S2CID 16763139.
  12. ^Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations".Nature Biotechnology.19 (1):45–50.doi:10.1038/83496.PMID 11135551.S2CID 15491882.
  13. ^Kell, D. B.; Dobson, P. D.; Bilsland, E.;Oliver, S. G. (2012). "The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: What we (need to) know and how we can do so".Drug Discovery Today.18 (5–6):218–39.doi:10.1016/j.drudis.2012.11.008.PMID 23207804.
  14. ^Lanthaler, K.; Bilsland, E.; Dobson, P. D.; Moss, H. J.; Pir, P. N.;Kell, D. B.;Oliver, S. G. (2011)."Genome-wide assessment of the carriers involved in the cellular uptake of drugs: A model system in yeast".BMC Biology.9: 70.doi:10.1186/1741-7007-9-70.PMC 3280192.PMID 22023736.
  15. ^Kell, D. B.; Dobson, P. D.; Oliver, S. G. (2011). "Pharmaceutical drug transport: The issues and the implications that it is essentially carrier-mediated only".Drug Discovery Today.16 (15–16):704–714.doi:10.1016/j.drudis.2011.05.010.PMID 21624498.
  16. ^Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010)."Further developments towards a genome-scale metabolic model of yeast".BMC Systems Biology.4: 145.doi:10.1186/1752-0509-4-145.PMC 2988745.PMID 21029416.
  17. ^Dobson, P. D.; Lanthaler, K.;Oliver, S. G.;Kell, D. B. (2009). "Implications of the dominant role of transporters in drug uptake by cells".Current Topics in Medicinal Chemistry.9 (2):163–181.doi:10.2174/156802609787521616.PMID 19200003.
  18. ^Herrgård, M. J.; Swainston, N.; Dobson, P.; Dunn, W. B.; Arga, K. Y. I.; Arvas, M.; Blüthgen, N.; Borger, S.; Costenoble, R.; Heinemann, M.; Hucka, M.; Le Novère, N.; Li, P.; Liebermeister, W.; Mo, M. L.; Oliveira, A. P.; Petranovic, D.;Pettifer, S.; Simeonidis, E.; Smallbone, K.;Spasić, I.; Weichart, D.; Brent, R.;Broomhead, D. S.;Westerhoff, H. V.; Kirdar, B. L.; Penttilä, M.; Klipp, E.;Palsson, B. Ø.; Sauer, U.;Oliver, S.G.;Mendes, P.; Nielsen, J.;Kell, D.B. (2008)."A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology".Nature Biotechnology.26 (10):1155–1160.doi:10.1038/nbt1492.PMC 4018421.PMID 18846089.
  19. ^Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.;Oliver, S.; Fields, S.;Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions".Nature.417 (6887):399–403.Bibcode:2002Natur.417..399V.doi:10.1038/nature750.PMID 12000970.S2CID 4419762.
  20. ^Oliver, S. G.; Williamson, D. H. (1976). "The molecular events involved in the induction of petite yeast mutants by fluorinated pyrimidines".MGG Molecular & General Genetics.146 (3):253–259.doi:10.1007/BF00701248.PMID 794690.S2CID 23632777.
  21. ^Oliver, S. G.; Van Der Aart, Q. J. M.; Agostoni-Carbone, M. L.; Aigle, M.; Alberghina, L.; Alexandraki, D.; Antoine, G.; Anwar, R.; Ballesta, J. P. G.; Benit, P.; Berben, G.; Bergantino, E.; Biteau, N.; Bolle, P. A.; Bolotin-Fukuhara, M.; Brown, A.; Brown, A. J. P.; Buhler, J. M.; Carcano, C.; Carignani, G.; Cederberg, H.; Chanet, R.; Contreras, R.; Crouzet, M.; Daignan-Fornier, B.; Defoor, E.; Delgado, M.; Demolder, J.; Doira, C.; et al. (1992). "The complete DNA sequence of yeast chromosome III".Nature.357 (6373):38–46.Bibcode:1992Natur.357...38O.doi:10.1038/357038a0.PMID 1574125.S2CID 4271784.
  22. ^King, P.; Rowland, J.; Aubrey, W.; Liakata, M.; Markham, M.; Soldatova, L. N.; Whelan, K. E.; Clare, A.; Young, M.; Sparkes, A.; Oliver, S. G.; Pir, P. (2009)."The Robot Scientist Adam".Computer.42 (7):46–54.doi:10.1109/MC.2009.270.S2CID 13920692.
  23. ^"UK Government Grants awarded to Stephen Oliver". Retrieved4 July 2014.
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