Sethupathis (lit. 'bridge lord') were 17th century rulers of the Ramnad and Sivaganga regions in southern India.

Sethupathi may also refer to:

• Sethupathi (surname)
• Sethupathi (film), a 2016 Indian Tamil-language film
• Sethupathi Higher Secondary School in Madurai, India
• Sethupathi, afictional character in the IndianBaahubali franchise

• Sethu (disambiguation)
• Pati (disambiguation)

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