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Selurampanel

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Selurampanel
Clinical data
ATC code
  • None
Identifiers
  • N-[7-Isopropyl-6-(2-methylpyrazol-3-yl)-2,4-dioxo-1H-quinazolin-3-yl]methanesulfonamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H19N5O4S
Molar mass377.42 g·mol−1
3D model (JSmol)
  • CC(C)c1cc2c(cc1c3ccnn3C)c(=O)n(c(=O)[nH]2)NS(=O)(=O)C
  • InChI=1S/C16H19N5O4S/c1-9(2)10-8-13-12(7-11(10)14-5-6-17-20(14)3)15(22)21(16(23)18-13)19-26(4,24)25/h5-9,19H,1-4H3,(H,18,23)
  • Key:MCECSFFXUPEPDB-UHFFFAOYSA-N

Selurampanel (INN, code nameBGG492) is adrug closely related to thequinoxalinedione series which acts as acompetitive antagonist of theAMPA andkainate receptors and, as of 2015, is being investigated inclinical trials byNovartis for the treatment ofepilepsy.[1][2][3] It has also been studied in the acute treatment ofmigraine, and was found to produce some pain relief, but with a relatively high rate ofside effects.[4]

References

[edit]
  1. ^Faught E (January 2014). "BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy".Expert Opinion on Investigational Drugs.23 (1):107–113.doi:10.1517/13543784.2014.848854.PMID 24147649.S2CID 40105670.
  2. ^Belcastro V, Verrotti A (2015). "Novel Molecular Targets for Drug-Treatment of Epilepsy". In Striano P (ed.).Epilepsy Towards the Next Decade. Contemporary Clinical Neuroscience. pp. 183–199.doi:10.1007/978-3-319-12283-0_10.ISBN 978-3-319-12282-3.
  3. ^Hanada T (2014)."The AMPA receptor as a therapeutic target in epilepsy: preclinical and clinical evidence".Journal of Receptor, Ligand and Channel Research: 39.doi:10.2147/JRLCR.S51475.ISSN 1178-699X.
  4. ^Gomez-Mancilla B, Brand R, Jürgens TP, Göbel H, Sommer C, Straube A, et al. (February 2014)."Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks".Cephalalgia.34 (2):103–113.doi:10.1177/0333102413499648.PMID 23963355.S2CID 206520491.
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AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
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