Protein-coding gene in the species Homo sapiens
Sarcolipin is amicropeptide protein that in humans is encoded by theSLN gene .[ 3] [ 4]
Sarcoplasmic reticulum Ca2+ -ATPases are transmembrane proteins that catalyze theATP -dependent transport ofCa2+ from the cytosol into the lumen of thesarcoplasmic reticulum in muscle cells. The SLN gene encodes a small transmembrane proteolipid that regulates several sarcoplasmic reticulum Ca2+ -ATPases by reducing the accumulation of Ca2+ in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis.[ 4]
Ablation of sarcolipin increases atrial Ca2+ transient amplitudes and enhancedatrial contractility . Furthermore, atria from sarcolipin-null mice have blunted response toisoproterenol stimulation, implicating sarcolipin as a mediator ofbeta-adrenergic responses in atria.[ 5]
sarcoplasmic reticulum Ca2+ -ATPases to stop pumping Ca2+ ions but continue futilely hydrolysing ATP, thus releasing the energy as heat.[ 6] [ 7] brown adipose tissue and beige adipose tissue.[ 8] opah heat its body. Some fishes like thebillfishes have a specialised brain heater tissue that is derived from muscles that cannot contract but specialise in producing heat using sarcolipin.
SLN (gene) has been shown tointeract withPLN [ 9] [ 10] ATP2A1 .[ 9] [ 10]
^a b c GRCh38: Ensembl release 89: ENSG00000170290 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Odermatt A, Taschner PE, Scherer SW, Beatty B, Khanna VK, Cornblath DR, et al. (November 1997)."Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease" .Genomics .45 (3):541– 53.doi :10.1006/geno.1997.4967 .hdl :2066/25426 PMID 9367679 .S2CID 41989102 . ^a b "Entrez Gene: SLN sarcolipin" .^ Babu GJ, Bhupathy P, Timofeyev V, Petrashevskaya NN, Reiser PJ, Chiamvimonvat N, Periasamy M (November 2007)."Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility" .Proceedings of the National Academy of Sciences of the United States of America .104 (45):17867– 72.Bibcode :2007PNAS..10417867B .doi :10.1073/pnas.0707722104 PMC 2077025 PMID 17971438 . ^ Bal NC, Periasamy M (March 2020)."Uncoupling of sarcoendoplasmic reticulum calcium ATPase pump activity by sarcolipin as the basis for muscle non-shivering thermogenesis" .Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences .375 (1793): 20190135.doi :10.1098/rstb.2019.0135 .PMC 7017432 PMID 31928193 . ^ Legendre LJ, Davesne D (March 2020)."The evolution of mechanisms involved in vertebrate endothermy" .Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences .375 (1793): 20190136.doi :10.1098/rstb.2019.0136 PMC 7017440 PMID 31928191 . ^ Reilly SM, Saltiel RA (22 October 2015)."A Futile Approach to Fighting Obesity?" .Cell .163 (3):539– 540.doi :10.1016/j.cell.2015.10.006 PMID 26496598 .S2CID 10336243 . ^a b Asahi M, Sugita Y, Kurzydlowski K, De Leon S, Tada M, Toyoshima C, MacLennan DH (April 2003)."Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban" .Proceedings of the National Academy of Sciences of the United States of America .100 (9):5040– 5.Bibcode :2003PNAS..100.5040A .doi :10.1073/pnas.0330962100 PMC 154294 PMID 12692302 . ^a b Asahi M, Kurzydlowski K, Tada M, MacLennan DH (July 2002)."Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)" .The Journal of Biological Chemistry .277 (30):26725– 8.doi :10.1074/jbc.C200269200 PMID 12032137 .
Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, et al. (January 1996)."Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization" .Genome Research .6 (1):35– 42.doi :10.1101/gr.6.1.35 PMID 8681137 . Odermatt A, Becker S, Khanna VK, Kurzydlowski K, Leisner E, Pette D, MacLennan DH (May 1998)."Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase" .The Journal of Biological Chemistry .273 (20):12360– 9.doi :10.1074/jbc.273.20.12360 PMID 9575189 . Smith WS, Broadbridge R, East JM, Lee AG (January 2002)."Sarcolipin uncouples hydrolysis of ATP from accumulation of Ca2+ by the Ca2+-ATPase of skeletal-muscle sarcoplasmic reticulum" .The Biochemical Journal .361 (Pt 2):277– 86.doi :10.1042/0264-6021:3610277 .PMC 1222307 PMID 11772399 . Mascioni A, Karim C, Barany G, Thomas DD, Veglia G (January 2002). "Structure and orientation of sarcolipin in lipid environments".Biochemistry .41 (2):475– 82.doi :10.1021/bi011243m .PMID 11781085 . Asahi M, Kurzydlowski K, Tada M, MacLennan DH (July 2002)."Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)" .The Journal of Biological Chemistry .277 (30):26725– 8.doi :10.1074/jbc.C200269200 PMID 12032137 . Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R (March 2003)."Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling" .The Journal of Biological Chemistry .278 (11):9570– 5.doi :10.1074/jbc.M213132200 PMID 12645548 . Asahi M, Sugita Y, Kurzydlowski K, De Leon S, Tada M, Toyoshima C, MacLennan DH (April 2003)."Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban" .Proceedings of the National Academy of Sciences of the United States of America .100 (9):5040– 5.Bibcode :2003PNAS..100.5040A .doi :10.1073/pnas.0330962100 PMC 154294 PMID 12692302 . Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004)."Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" .Genome Research .14 (9):1711– 8.doi :10.1101/gr.2435604 .PMC 515316 PMID 15342556 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature .437 (7062):1173– 8.Bibcode :2005Natur.437.1173R .doi :10.1038/nature04209 .PMID 16189514 .S2CID 4427026 . Vittorini S, Storti S, Parri MS, Cerillo AG, Clerico A (2007)."SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects" .Molecular Medicine .13 (1– 2):105– 11.doi :10.2119/2006-00054.Vittorini .PMC 1869624 PMID 17515962 .
