TheEta variant is avariant ofSARS-CoV-2, thevirus that causesCOVID-19.The Eta variant or lineageB.1.525, also calledVUI-21FEB-03 (previouslyVUI-202102/03) by Public Health England (PHE) and formerly known asUK1188,21D or20A/S:484K, does not carry the same N501Y mutation found inAlpha,Beta andGamma, but carries the same E484K-mutation as found in the Gamma, Zeta, and Beta variants, and also carries the same ΔH69/ΔV70 deletion (a deletion of the amino acidshistidine andvaline in positions 69 and 70) as found in Alpha, N439K variant (B.1.141 and B.1.258) and Y453F variant (Cluster 5).[1]
Eta differs from all other variants by having both the E484K-mutation and a new F888L mutation (a substitution ofphenylalanine (F) withleucine (L) in the S2 domain of thespike protein). As of 5 March 2021, it had been detected in 23 countries.[2][3][4] It has also been reported inMayotte, theoverseas department/region ofFrance.[2] The first cases were detected in December 2020 in the UK and Nigeria, and as of 15 February, it had occurred in the highest frequency among samples in the latter country.[4] As of 24 February, 56 cases were found in the UK. Denmark, which sequences all its COVID-19 cases, found 113 cases of this variant from January 14 to February 21, of which seven were directly related to foreign travels to Nigeria.[3]
UK experts are studying it to understand how much of a risk it could be. It is currently regarded as a "variant under investigation", but pending further study, it may become a "variant of concern".Prof Ravi Gupta, from theUniversity of Cambridge spoke to theBBC and said lineage B.1.525 appeared to have "significant mutations" already seen in some of the other newer variants, which is partly reassuring as their likely effect is to some extent more predictable.[citation needed]
Under the simplified naming scheme proposed by theWorld Health Organization, lineage B.1.525 has been labelled variant Eta.[citation needed]
![Amino acid mutations of SARS-CoV-2 Eta variant plotted on a genome map of SARS-CoV-2 with a focus on the spike.[5]](/mt/?noimg=&dark=on&url=https%3a%2f%2fwikipedia.org%2fwiki%2fFile%3aSARS-CoV-2_Eta_variant.svg)
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| Country | Confirmed cases (GISAID)[6] as of 27 August 2021 | Last Reported Case |
|---|---|---|
 Canada | 1,403 | |
 USA | 1,184 | 11 June 2021 |
 Germany | 738 | 23 June 2021 |
 France | 686 | 8 June 2021 |
 Denmark | 613 | 24 May 2021 |
 United Kingdom | 517 | 31 May 2021 |
 Italy | 397 | 22 June 2021 |
 Nigeria | 255 | 21 May 2021 |
 India | 221 | 31 May 2021 |
 Spain | 174 | 18 June 2021 |
 Norway | 81 | 9 May 2021 |
 Belgium | 74 | 22 June 2021 |
 Ireland | 71 | 29 May 2021 |
 Switzerland | 55 | 13 June 2021 |
 Netherlands | 54 | 31 May 2021 |
 Luxembourg | 52 | 20 May 2021 |
 Slovenia | 52 | 8 April 2021 |
 Turkey | 47 | 31 March 2021 |
 Ghana | 38 | 4 April 2021 |
 Uganda | 37 | 12 May 2021 |
 South Sudan | 36 | 3 April 2021 |
 Finland | 25 | 9 April 2021 |
 Togo | 25 | 25 February 2021 |
 Portugal | 24 | 11 June 2021 |
 Bangladesh | 18 | 15 June 2021 |
 Austria | 17 | 30 April 2021 |
 Israel | 17 | 18 May 2021 |
 Japan | 17 | 2 June 2021 |
 Australia | 15 | 31 May 2021 |
 Kenya | 13 | 30 April 2021 |
 Malta | 13 | 21 June 2021 |
 South Africa | 13 | 26 May 2021 |
 Cote d'Ivoire | 10 | 25 February 2021 |
 Poland | 10 | 14 March 2021 |
 Singapore | 10 | 27 April 2021 |
 Sweden | 8 | 14 April 2021 |
 Angola | 7 | 16 April 2021 |
 Cameroon | 7 | 2 March 2021 |
 Niger | 6 | 1 April 2021 |
 Philippines | 6 | 24 March 2021 |
 Guinea | 5 | |
 Indonesia | 5 | 5 May 2021 |
 Kuwait | 5 | 5 June 2021 |
 Rwanda | 5 | 28 January 2021 |
 Costa Rica | 4 | 28 March 2021 |
| Reunion | 4 | 25 May 2021 |
 Malaysia | 3 | 27 March 2021 |
 Mali | 3 | 4 April 2021 |
 Greece | 2 | 9 April 2021 |
| Guadeloupe | 2 | 11 March 2021 |
 Jordan | 2 | 7 January 2021 |
| Mayotte | 2 | 29 March 2021 |
 Qatar | 2 | 15 April 2021 |
 Russia | 2 | 11 May 2021 |
 South Korea | 2 | 26 February 2021 |
 Thailand | 2 | 1 March 2021 |
 Argentina | 1 | 4 May 2021 |
 Belarus | 1 | 22 March 2021 |
 Brazil | 1 | 15 February 2021 |
 Estonia | 1 | 29 March 2021 |
 Gabon | 1 | 30 March 2021 |
 Gambia | 1 | |
 Latvia | 1 | 26 April 2021 |
 Morocco | 1 | 2 March 2021 |
 Senegal | 1 | 11 May 2021 |
 Sri Lanka | 1 | 28 April 2021 |
 Tunisia | 1 | 5 March 2021 |
 Armenia | 3 | 5 August 2021 |
 Bhutan | 1 | |
 Gibraltar | 2 | |
 Kyrgyzstan | 16 | 17 June 2021 |
| World (71 countries) | Total:7,129 | Total as of 27 August 2021 |
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