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Russell Doolittle

From Wikipedia, the free encyclopedia
American biochemist (1931–2019)
Department of Chemistry and Biochemistry, UC San Diego

Russell F. Doolittle (January 10, 1931 – October 11, 2019) was an Americanbiochemist who taught at theUniversity of California, San Diego (UCSD). Described as a "world-renowned evolutionary biologist",[1] Doolittle's research primarily focused on the structure and evolution of proteins.[2] Highlights of Doolittle's decades of research include his role in co-developing thehydropathy index and determining the structure offibrinogen.

Early life and education

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Doolittle was born on January 10, 1931, inNew Haven, Connecticut.[3] Doolittle earned a B.A. in biology fromWesleyan University in 1952, and an M.A. in education fromTrinity College in 1957.[4] He earned his Ph.D. in biochemistry atHarvard University in 1962 with research inblood clotting. Doolittle later conductedpostdoctoral research inSweden funded by theNational Institutes of Health (NIH).

Career

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Doolittle notably co-developed thehydropathy index, and was instrumental in determining the structure offibrinogen. Dootlittle was a member of theNational Academy of Sciences from 1984,[5] was aGuggenheim Fellow and was a co-recipient of thePaul Ehrlich Prize.[2]

In 1985, Doolittle was elected a Fellow of theAmerican Academy of Arts and Sciences in 1985.[6] In 1992, he was elected to theAmerican Philosophical Society.[7] In addition, Doolittle calculated the date of thedivergence of all life forms from acommon ancestor.[8] In 2006, Doolittle was awarded theJohn J. Carty Award from the National Academy of Sciences for his professional achievements.[9]

Personal views

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Doolittle was a critic ofcreationism[10] andintelligent design (ID), and accusedMichael Behe, an ID proponent, of misquoting his work.[11] In 1981, Doolittle debated ID proponentDuane Gish on live television.[12] In 2016, three years before is death, Doolittle signed onto an open letter urging world leaders to take the threat ofclimate change seriously.[13]

Death and legacy

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Doolittle died inLa Jolla on October 11, 2019, at the age of 88.[14][15] Molecular biologistKenneth R. Miller praised Doolittle's contributions to science, stating he regards Doolittle "as the very epitome of a humane life in science".[16]

Books

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  • Russell F. Doolittle,Of Urfs and Orfs: A Primer on how to Analyze Derived Amino Acid Sequences. (University Science Books, December 1986)ISBN 0-935702-54-7
  • Russell F. Doolittle, John N. Abelson, and Melvin I. Simon,Computer Methods for Macromolecular Sequence Analysis (Methods in Enzymology) (Academic Press, 1996)ISBN 0-12-182167-6
  • Russell F. Doolittle,The Evolution of Vertebrate Blood Clotting (University Science Books, August 2012)ISBN 978-1-891389-81-8
  • John N. Abelson, Melvin I. Simon, and Russell F. Doolittle,Molecular Evolution: Computer Analysis of Protein and Nucleic Acid Sequences, Volume 183: Volume 183: Molecular Evolution (Methods in Enzymology) (Academic Press, Feb 28, 1990)ISBN 0-12-182084-X
  • Mosesson, Michael W. and Doolittle, Russell F.Molecular biology of fibrinogen and fibrin (Annals of the New York Academy of Sciences) (New York Academy of Sciences, 1983)ISBN 0-89766-209-1

References

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  1. ^Fogg, Christiana; Kovats, Diane; Vingron, Martin (4 August 2021)."ISCB Honors 2021 Award Recipients Peer Bork, Barbara Engelhardt, Ben Raphael, Teresa Attwood".Bioinformatics.37 (Supplement_1):i1 –i6.doi:10.1093/bioinformatics/btab383.PMC 8275334.PMID 34252962.
  2. ^ab"Russell Doolittle".University of California, San Diego. 2008. Retrieved2008-12-12.
  3. ^"In Memoriam: Russell Doolittle, 1931-2019".biology.ucsd.edu. Retrieved2021-10-05.
  4. ^Doolittle, Russell (2008)."Biography of Dr Doolittle"(PDF). University of California, San Diego. Retrieved2008-12-12.
  5. ^"Russell F. Doolittle".www.nasonline.org. Retrieved2022-03-31.
  6. ^"Book of Members, 1780-2010: Chapter D"(PDF). American Academy of Arts and Sciences. Retrieved22 April 2011.
  7. ^"APS Member History".search.amphilsoc.org. Retrieved2022-03-31.
  8. ^Menon, Shanti (June 1996)."A new tree of life - Russell Doolittle calculates a new, more recent date for the divergence of all life forms from a common ancestor".Discover. Retrieved2008-12-12.
  9. ^"John J. Carty Award for the Advancement of Science". National Academy of Sciences. Archived fromthe original on 29 December 2010. Retrieved25 February 2011.
  10. ^Russell Doolittle, "The Probability and Origin of Life" inScientists Confront Creationism (1984) Ed. Laurie R. Godfrey, p. 85
  11. ^Doolittle, Russell (February–March 1997)."A Delicate Balance".Boston Review. Archived fromthe original on 2014-02-03. Retrieved2008-12-12.
  12. ^"Russell Doolittle dies | National Center for Science Education".ncse.ngo. Retrieved2021-10-05.
  13. ^"An Open Letter Regarding Climate Change From Concerned Members of the U.S. National Academy of Sciences | Earth Research Institute".www.eri.ucsb.edu. Retrieved2021-10-05.
  14. ^"Doolittle Announcement".University of California San Diego Dept. of Chemistry and Biochemistry NewsNews. University of California San Diego. Retrieved10 November 2019.
  15. ^"In Memoriam: Russell Doolittle, 1931-2019".biology.ucsd.edu. Retrieved2021-10-05.
  16. ^Farrell, John."The Achievement Of Russell Doolittle".Forbes. Retrieved2021-10-05.

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