Robert Francis Furchgott (June 4, 1916 – May 19, 2009) was an Americanbiochemist winningNobel Prize who contributed to the discovery of nitric oxide as a transient cellular signal inmammalian systems.
In 1978, Furchgott discovered a substance inendothelial cells that relaxesblood vessels, calling itendothelium-derived relaxing factor (EDRF).[2] By 1986, he had worked out EDRF's nature and mechanism of action, and determined that EDRF was in factnitric oxide (NO), an important compound in many aspects of cardiovascular physiology. This research is important in explaining a wide variety of neuronal, cardiovascular, and general physiologic processes of central importance in human health and disease.[3]
Furchgott was Jewish[15] and lived most of his married and career life inWoodmere, New York onLong Island. He was married to Lenore Mandelbaum (February 1915 – April 1983)[16] from 1941 until her death at age 68. They had three daughters: Jane, Terry, and Susan. His daughter, Susan, was an artist in the San Francisco counter-culture and co-founder of theKerista Commune.
Anon. (2009) "Obituary: Robert Furchgott,"The Telegraph (online), May 26, 2009, see,[19] accessed 11 August 2015.
Raju, T N (2000), "The Nobel chronicles. 1998: Robert Francis Furchgott (b 1911), Louis J Ignarro (b 1941), and Ferid Murad (b 1936).",Lancet, vol. 356, no. 9226 (published Jul 22, 2000), p. 346,doi:10.1016/s0140-6736(05)73635-7,PMID11071225,S2CID53221905
Rabelink, A J (1998), "Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signalling molecule",Nederlands Tijdschrift voor Geneeskunde, vol. 142, no. 52 (published Dec 26, 1998), pp. 2828–30,PMID10065255
Laufs, U; Erdmann, E (1998), "Nitric oxide as a signal molecule in the cardiovascular system. Nobel Prize for Medicine in 1998",Dtsch. Med. Wochenschr., vol. 123, no. 51–52 (published Dec 18, 1998), pp. 1562–5,doi:10.1055/s-0029-1237297,PMID9893684,S2CID68505199
Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "The Nobel Prize 1998 in physiology or medicine. Nitrogen oxide as a signal molecule in the cardiovascular system",Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), pp. 7571–8,PMID9889673
Nielsen, T T; Sørensen, K E (1998), "Discovery of "endogenous nitroglycerin", NO, as cellular signal molecule",Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), p. 7567,PMID9889670
Mitka, M (1998), "1998 Nobel Prize winners are announced: three discoverers of nitric oxide activity",JAMA, vol. 280, no. 19 (published Nov 18, 1998), p. 1648,doi:10.1001/jama.280.19.1648,PMID9831980
Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "1998 Nobel Prize in physiology or medicine. Nitric oxide as a signal molecule in the cardiovascular system",Läkartidningen, vol. 95, no. 43 (published Oct 21, 1998), pp. 4703–8,PMID9821753
^Raju, T N (2000), "The Nobel chronicles. 1998: Robert Francis Furchgott (b 1911), Louis J Ignarro (b 1941), and Ferid Murad (b 1936).",Lancet, vol. 356, no. 9226 (published Jul 22, 2000), p. 346,doi:10.1016/s0140-6736(05)73635-7,PMID11071225,S2CID53221905
^Rabelink, A J (1998), "Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signalling molecule",Nederlands Tijdschrift voor Geneeskunde, vol. 142, no. 52 (published Dec 26, 1998), pp. 2828–30,PMID10065255
^Laufs, U; Erdmann, E (1998), "Nitric oxide as a signal molecule in the cardiovascular system. Nobel Prize for Medicine in 1998",Dtsch. Med. Wochenschr., vol. 123, no. 51–52 (published Dec 18, 1998), pp. 1562–5,doi:10.1055/s-0029-1237297,PMID9893684,S2CID68505199
^Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "The Nobel Prize 1998 in physiology or medicine. Nitrogen oxide as a signal molecule in the cardiovascular system",Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), pp. 7571–8,PMID9889673
^Nielsen, T T; Sørensen, K E (1998), "Discovery of "endogenous nitroglycerin", NO, as cellular signal molecule",Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), p. 7567,PMID9889670
^Mitka, M (1998), "1998 Nobel Prize winners are announced: three discoverers of nitric oxide activity",JAMA, vol. 280, no. 19 (published Nov 18, 1998), p. 1648,doi:10.1001/jama.280.19.1648,PMID9831980
^Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "1998 Nobel Prize in physiology or medicine. Nitric oxide as a signal molecule in the cardiovascular system",Läkartidningen, vol. 95, no. 43 (published Oct 21, 1998), pp. 4703–8,PMID9821753
^BBC News vom 23. Mai 2009:US „Viagra scientist“ dies at 92.
^Furchgott, R.F. (1996), "The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide",JAMA, vol. 276, no. 14 (published Oct 9, 1996), pp. 1186–8,doi:10.1001/jama.276.14.1186,PMID8827976
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