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Revefenacin

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Revefenacin
Clinical data
Trade namesYupelri
AHFS/Drugs.comMonograph
MedlinePlusa619009
License data
Routes of
administration
Inhalation
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC35H43N5O4
Molar mass597.760 g·mol−1
3D model (JSmol)
  • CN(CCN1CCC(CC1)OC(=O)NC2=CC=CC=C2C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)CN5CCC(CC5)C(=O)N
  • InChI=1S/C35H43N5O4/c1-38(34(42)29-13-11-26(12-14-29)25-40-19-15-28(16-20-40)33(36)41)23-24-39-21-17-30(18-22-39)44-35(43)37-32-10-6-5-9-31(32)27-7-3-2-4-8-27/h2-14,28,30H,15-25H2,1H3,(H2,36,41)(H,37,43)
  • Key:FYDWDCIFZSGNBU-UHFFFAOYSA-N

Revefenacin, sold under the brand nameYupelri, is amedication for the treatment ofchronic obstructive pulmonary disease (COPD). It was approved for use in the United States in 2018.[1] It wasdeveloped by Theravance Biopharma and is marketed byMylan. Revefenacin isformulated as a solution that isnebulized and inhaled.[2]

Revefenacin is abronchodilator that exerts its effect as a long-actingmuscarinic antagonist.[3]

Society and culture

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Brand names

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In some countries, Yupelri is marketed byViatris after Upjohn merged with Mylan to create Viatris.[4][5]

References

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  1. ^"Theravance Biopharma and Mylan Receive FDA Approval for Yupelri (revefenacin) in Adults with Chronic Obstructive Pulmonary Disease" (Press release). Mylan. 9 November 2018. Archived fromthe original on 15 September 2019. Retrieved17 January 2019.
  2. ^Heo YA (January 2019)."Revefenacin: First Global Approval".Drugs.79 (1):85–91.doi:10.1007/s40265-018-1036-x.PMC 6445810.PMID 30560478.
  3. ^Donohue JF, Kerwin E, Barnes CN, Moran EJ, Haumann B, Crater GD (May 2020)."Efficacy of revefenacin, a long-acting muscarinic antagonist for nebulized therapy, in patients with markers of more severe COPD: a post hoc subgroup analysis".BMC Pulmonary Medicine.20 (1): 134.doi:10.1186/s12890-020-1156-4.PMC 7216337.PMID 32393215.
  4. ^"Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Pfizer. 16 November 2020. Retrieved17 June 2024 – via Business Wire.
  5. ^"Brands".Viatris. 16 November 2020. Retrieved17 June 2024.
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