Retinoid X receptor gamma (RXR-gamma), also known asNR2B3 (nuclear receptor subfamily 2, group B, member 3) is anuclear receptor that in humans is encoded by theRXRGgene.[5][6]
This gene encodes a member of theretinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects ofretinoic acid (RA). This receptor forms heterodimers with theretinoic acid,thyroid hormone, andvitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells.Alternate transcriptional splice variants, encoding differentisoforms, have been characterized.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors".Genomics.20 (3):397–403.doi:10.1006/geno.1994.1193.PMID8034312.
Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently".Cell.68 (2):377–95.doi:10.1016/0092-8674(92)90478-U.PMID1310259.S2CID40617478.
Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y, Seldin MF, Ozato K, Inoko H, Taketo M (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human".Immunogenetics.41 (2–3):83–90.doi:10.1007/BF00182317.PMID7806300.S2CID29455544.
Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas".Neuroendocrinology.65 (4):299–306.doi:10.1159/000127188.PMID9143002.
Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation".Histochem. J.29 (2):127–33.doi:10.1023/A:1026481205135.PMID9147069.S2CID24005650.
Kim SW, Kim HJ, Jung DJ, Lee SK, Kim YS, Kim JH, Kim TS, Lee JW (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins".Oncogene.20 (45):6638–42.doi:10.1038/sj.onc.1204695.PMID11641790.S2CID7377737.
Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S, Tsao-Wei DD, Park J, Salonga D, Hölscher AH, Danenberg PV (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer".Clin. Cancer Res.8 (2):438–43.PMID11839661.
Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas".Placenta.23 (8–9):661–71.doi:10.1053/plac.2002.0855.PMID12361685.
Kimura Y, Suzuki T, Kaneko C, Darnel AD, Moriya T, Suzuki S, Handa M, Ebina M, Nukiwa T, Sasano H (2003). "Retinoid receptors in the developing human lung".Clin. Sci.103 (6):613–21.doi:10.1042/cs1030613.PMID12444914.
