Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Renal glycosuria

From Wikipedia, the free encyclopedia
Medical condition
Renal glycosuria
Other namesBenign glycosuria, familial renal glycosuria, nondiabetic glycosuria, primary renal glycosuria, diabetes renalis, renal diabetes, diabetes innocence, low renal threshold, renal glucosuria
Glucose
SpecialtyMedical genetics

Renal glycosuria is a rare condition in which the simplesugarglucose is excreted in the urine[1] despite normal or low blood glucose levels. With normal kidney (renal) function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in the blood. However, in those with renalglycosuria, glucose is abnormally elevated in the urine due to improper functioning of the renal tubules, which are primary components ofnephrons, thefiltering units of the kidneys.

Signs and symptoms

[edit]

In most affected individuals, the condition causes no apparentsymptoms (asymptomatic) or serious effects. When renal glycosuria occurs as an isolated finding with otherwise normal kidney function, the condition is thought to be inherited as an autosomalrecessive trait[citation needed].

Causes

[edit]

Renal glycosuria can result fromFanconi syndrome (with impaired absorption of phosphate, amino acids) or familial renal glucosuria (presents as isolated glucosuria).[2] Familial renal glycosuria (FRG) is caused by mutations ofSLC5A2, which codes for thesodium-glucose cotransporter 2.[3]

Additionally,SGLT2 inhibitor medications produce glycosuria as their primarymechanism of action, by inhibitingsodium/glucose cotransporter 2 in the kidneys and thereby interfering with renal glucose reabsorption.

Diagnosis

[edit]

A doctor normally can diagnose renal glycosuria when a routine urine test (Urinalysis) detects glucose in the urine, while a blood test indicates that the blood glucose level is normal.[citation needed]

Treatment

[edit]

The cause of glycosuria determines whether the condition is chronic or acute. However, the presence of glucose in urine is not necessarily a serious or life-threatening condition. Managing diabetes, hyperthyroidism and regular kidney function tests can help in reducing excretion of sugars in urine.[citation needed]

SGLT-2 inhibitor drugs like dapagliflozin and canagliflozin have recently been approved for lowering blood sugar levels in patients with type 2 diabetes mellitus.[4]

See also

[edit]

References

[edit]
  1. ^Khachadurian AK, Khachadurian LA (June 1964)."The Inheritance of Renal Glycosuria".Am. J. Hum. Genet.16:189–94.PMC 1932305.PMID 14174800.
  2. ^Liman, Maria Nataly P.; Jialal, Ishwarlal (2023),"Physiology, Glycosuria",StatPearls, Treasure Island (FL): StatPearls Publishing,PMID 32491373, retrieved2023-11-23
  3. ^"Renal Glucosuria".Medscape. Dec 10, 2018. RetrievedNov 23, 2023.
  4. ^Research, Center for Drug Evaluation and (2018-12-28)."Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors".FDA.

External links

[edit]
Classification
External resources
Sucrose, transport
(extracellular)
Disaccharide catabolism
Monosaccharide transport
Hexoseglucose
Monosaccharide catabolism
Fructose:
Galactose /galactosemia:
Glucoseglycogen
Glycogenesis
Glycogenolysis
Extralysosomal:
Lysosomal (LSD):
GlucoseCAC
Glycolysis
Gluconeogenesis
Pentose phosphate pathway
Other
Genetic disorder, membrane:Solute carrier disorders
1-10
11-20
21-40
51-60
Retrieved from "https://en.wikipedia.org/w/index.php?title=Renal_glycosuria&oldid=1186499087"
Category:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp