 | This articleis anorphan, as no other articleslink to it. Pleaseintroduce links to this page fromrelated articles; try theFind link tool for suggestions.(October 2019) |
Rck-2 is agene that plays a major role in clock control oftranslation. Rck-2 protein is akinase and is rhythmically activated throughphosphorylation events based on the periodicity of the clock. Rck-2 activation is directly associated with the phosphorylation ofeEF-2, which is an elongation factor that plays a major role in translation.[1] Phosphorylation of eEF-2 has an inhibitory effect on the activity of translation. Rck-2 is largely studied inNeurospora crassa but has significant homology to humans.[2] Knockout strains have been produced in the model organismN. crassa but there are no human pathologies associated with its deletion. While the basic mechanisms of circadian transcriptional control are known, little is understood about how the clock controlsmRNA translation, which makes the characterization of pathways responsible for translational control all the more important.