Thephosphate ororthophosphate ion[PO4]3− is derived from phosphoric acid by the removal of threeprotonsH+. Removal of one proton gives thedihydrogen phosphate ion[H2PO4]− while removal of two protons gives thehydrogen phosphate ion[HPO4]2−. These names are also used for salts of those anions, such asammonium dihydrogen phosphate andtrisodium phosphate.
Inorganic chemistry,phosphate ororthophosphate is anorganophosphate, an ester of orthophosphoric acid of the formPO4RR′R″ where one or more hydrogen atoms are replaced byorganic groups. An example istrimethyl phosphate,(CH3)3PO4. The term also refers to thetrivalent functional groupOP(O−)3 in such esters. Phosphates may contain sulfur in place of one or more oxygen atoms (thiophosphates andorganothiophosphates).
The phosphate ion has amolar mass of 94.97 g/mol, and consists of a centralphosphorus atom surrounded by fouroxygen atoms in atetrahedral arrangement. It is theconjugate base of the hydrogen phosphate ion[HPO4]2−, which in turn is the conjugate base of the dihydrogen phosphate ion[H2PO4]−, which in turn is the conjugate base oforthophosphoric acid,H3PO4.
Many phosphates aresoluble inwater atstandard temperature and pressure. The sodium, potassium,rubidium,caesium, andammonium phosphates are all water-soluble. Most other phosphates are only slightly soluble or are insoluble in water. As a rule, the hydrogen and dihydrogen phosphates are slightly more soluble than the corresponding phosphates.
The pKa values are thepH values where the concentration of each species is equal to that of itsconjugate bases. At pH 1 or lower, the phosphoric acid is practically undissociated. Around pH 4.7 (mid-way between the first two pKa values) the dihydrogen phosphate ion,[H2PO4]−, is practically the only species present. Around pH 9.8 (mid-way between the second and third pKa values) the monohydrogen phosphate ion,[HPO4]2−, is the only species present. At pH 13 or higher, the acid is completely dissociated as the phosphate ion,[PO4]3−.
This means that salts of the mono- and di-phosphate ions can be selectively crystallised from aqueous solution by setting the pH value to either 4.7 or 9.8.
In effect,H3PO4,[H2PO4]− and[HPO4]2− behave as separateweak acids because the successive pKa differ by more than 4.
Phosphate can form manypolymeric ions such aspyrophosphate,[P2O7]4−, andtriphosphate,[P3O10]5−. The variousmetaphosphate ions (which are usually long linear polymers) have an empirical formula of[PO3]− and are found in many compounds.
Inbiological systems, phosphorus can be found as free phosphate anions in solution (inorganic phosphate) or bound to organic molecules as variousorganophosphates.[5]
Inorganic phosphate is generally denotedPi and at physiological (homeostatic)pH primarily consists of a mixture of[HPO4]2− and[H2PO4]− ions. At a neutral pH, as in thecytosol (pH = 7.0), the concentrations of the orthophoshoric acid and its three anions have the ratios
Thus, only the[H2PO4]− and[HPO4]2− ions are present in significant amounts in the cytosol (62%[H2PO4]−, 38%[HPO4]2−). In extracellular fluid (pH = 7.4), this proportion is inverted (61%[HPO4]2−, 39%[H2PO4]−).
Inorganic phosphate can also be present aspyrophosphate anions[P2O7]4−, which give orthophosphate byhydrolysis:
An important occurrence of phosphates in biological systems is as the structural material of bone and teeth. These structures are made of crystallinecalcium phosphate in the form ofhydroxyapatite. The hard dense enamel ofmammalian teeth may containfluoroapatite, ahydroxy calcium phosphate where some of thehydroxyl groups have been replaced byfluoride ions.
Phosphates are medicinal salts of phosphorus. Some phosphates, which help cure manyurinary tract infections, are used to make urine more acidic. To avoid the development ofcalcium stones in the urinary tract, some phosphates are used.[6] For patients who are unable to get enough phosphorus in their daily diet, phosphates are used as dietary supplements, usually because of certain disorders or diseases.[6] Injectable phosphates can only be handled by qualified health care providers.[6]
Hyperphosphatemia, or a high blood level of phosphates, is associated with elevatedmortality in the general population. The most common cause of hyperphosphatemia in people, dogs, and cats is kidney failure. In cases of hyperphosphatemia, limiting consumption of phosphate-rich foods, such as some meats and dairy items and foods with a high phosphate-to-protein ratio, such as soft drinks, fast food, processed foods, condiments, and other products containing phosphate-salt additives is advised.[7]
Phosphates are the naturally occurring form of the elementphosphorus, found in manyphosphate minerals. In mineralogy and geology, phosphate refers to a rock or ore containing phosphate ions. Inorganic phosphates aremined to obtain phosphorus for use in agriculture and industry.[2]
The largest global producer and exporter of phosphates isMorocco. Within North America, the largest deposits lie in theBone Valley region of centralFlorida, theSoda Springs region of southeasternIdaho, and the coast ofNorth Carolina. Smaller deposits are located inMontana,Tennessee,Georgia, andSouth Carolina. The small island nation ofNauru and its neighborBanaba Island, which used to have massive phosphate deposits of the best quality, have been mined excessively. Rock phosphate can also be found in Egypt, Israel, Palestine, Western Sahara,Navassa Island, Tunisia, Togo, and Jordan, countries that have large phosphate-mining industries.
In 2007, at the current rate of consumption, the supply of phosphorus was estimated to run out in 345 years.[9] However, some scientists thought that a "peak phosphorus" would occur in 30 years andDana Cordell from Institute for Sustainable Futures said that at "current rates, reserves will be depleted in the next 50 to 100 years".[10] Reserves refer to the amount assumed recoverable at current market prices. In 2012 theUSGS estimated world reserves at 71 billion tons, while 0.19 billion tons were mined globally in 2011.[11] Phosphorus comprises 0.1% by mass of the average rock[12] (while, for perspective, its typical concentration in vegetation is 0.03% to 0.2%),[13] and consequently there are quadrillions of tons of phosphorus in Earth's 3×1019-ton crust,[14] albeit at predominantly lower concentration than the deposits counted as reserves, which are inventoried and cheaper to extract. If it is assumed that the phosphate minerals inphosphate rock are mainly hydroxyapatite and fluoroapatite, phosphate minerals contain roughly 18.5% phosphorus by weight. If phosphate rock contains around 20% of these minerals, the average phosphate rock has roughly 3.7% phosphorus by weight.
Some phosphate rock deposits, such asMulberry in Florida,[15] are notable for their inclusion of significant quantities of radioactive uranium isotopes. This is a concern because radioactivity can be released into surface waters[16] from application of the resultingphosphate fertilizer.
In December 2012,Cominco Resources announced an updatedJORC compliant resource of their Hinda project inCongo-Brazzaville of 531 million tons, making it the largest measured and indicated phosphate deposit in the world.[17]
Around 2018, Norway discovered phosphate deposits almost equal to those in the rest of Earth combined.[18][19]
In July 2022 China announced quotas on phosphate exportation.[20]
The largest importers in millions of metric tons of phosphate are Brazil 3.2, India 2.9 and the USA 1.6.[21]
Sea surface phosphate from theWorld Ocean AtlasRelationship of phosphate to nitrate uptake forphotosynthesis in various regions of the ocean. Note that nitrate is more often limiting than phosphate. See theRedfield ratio.
In ecological terms, because of its important role in biological systems, phosphate is a highly sought after resource. Once used, it is often a limiting nutrient inenvironments, and its availability may govern the rate of growth of organisms. This is generally true offreshwater environments, whereas nitrogen is more often the limiting nutrient in marine (seawater) environments. Addition of high levels of phosphate to environments and to micro-environments in which it is typically rare can have significant ecological consequences. For example, blooms in the populations of some organisms at the expense of others, and the collapse of populations deprived of resources such as oxygen (seeeutrophication) can occur. In the context of pollution, phosphates are one component oftotal dissolved solids, a major indicator of water quality, but not all phosphorus is in a molecular form that algae can break down and consume.[23]
Calcium hydroxyapatite and calcite precipitates can be found aroundbacteria inalluvial topsoil.[24] As clay minerals promote biomineralization, the presence of bacteria and clay minerals resulted in calcium hydroxyapatite and calcite precipitates.[24]
Phosphate deposits can contain significant amounts of naturally occurring heavy metals. Mining operations processingphosphate rock can leavetailings piles containing elevated levels ofcadmium,lead,nickel,copper,chromium, anduranium. Unless carefully managed, these waste products can leach heavy metals into groundwater or nearby estuaries. Uptake of these substances by plants and marine life can lead to concentration of toxic heavy metals in food products.[25]
^abc"Phosphate Primer".Florida Industrial and Phosphate Research Institute. Florida Polytechnic University.Archived from the original on 29 August 2017. Retrieved30 March 2018.
^Kipton J. Powell, Paul L. Brown, Robert H. Byrne, Tamás Gajda, Glenn Hefter, Staffan Sjöberg, Hans Wanner (2005): "Chemical speciation of environmentally significant heavy metals with inorganic ligands. Part 1: TheHg2+ , Cl−, OH−,CO2− 3,SO2− 4, andPO3− 4 aqueous systems".Pure and Applied Chemistry, volume 77, issue 4, pages 739–800.doi:10.1351/pac200577040739
^Hochanadel, Dave (December 10, 2010)."Limited amount of total phosphorus actually feeds algae, study finds". Lake Scientist. RetrievedJune 10, 2012.[B]ioavailable phosphorus – phosphorus that can be utilized by plants and bacteria – is only a fraction of the total, according to Michael Brett, a UW engineering professor ...
^Gnandi, K.; Tchangbedjil, G.; Killil, K.; Babal, G.; Abbel, E. (March 2006). "The Impact of Phosphate Mine Tailings on the Bioaccumulation of Heavy Metals in Marine Fish and Crustaceans from the Coastal Zone of Togo".Mine Water and the Environment.25 (1):56–62.Bibcode:2006MWE....25...56G.doi:10.1007/s10230-006-0108-4.S2CID129497587.
![[H 2PO 4]− Dihydrogen phosphate](/mt/?noimg=&dark=on&url=https%3a%2f%2fwikipedia.org%2fwiki%2fFile%3a2-dihydrogenphosphate-3D-balls.png)
![[HPO 4]2− Hydrogen phosphate](/mt/?noimg=&dark=on&url=https%3a%2f%2fwikipedia.org%2fwiki%2fFile%3a1-hydrogenphosphate-3D-balls.png)
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