PBX/Knotted 1 Homeobox 2 (PKNOX2) protein belongs to the three amino acid loop extension (TALE) class ofhomeodomain proteins, and is encoded byPKNOX2 gene in humans. The protein regulates the transcription of other genes and affects anatomical development.[5]
PKNOX2 protein regulates expression of other genes bybinding toDNA in a sequence-specific manner, i.e. to specific DNA sequences. It binds to unique DNA recognitionmotifs, acting as a nucleartranscription factor.[6] The nuclear transcription factor is a protein that regulatestranscription of genetic information fromDNA tomessenger RNA. Other functions of PKNOX2 includeactin filament binding. An importantparalog of thePKNOX2 gene isPKNOX1.
PKNOX2 belongs to the three amino acid loop extension (TALE) class of homeodomain proteins. This class is characterized by a 3-amino acid extension between alpha helix 1 and 2 in the homeodomain.[7]
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA binding domain and play a crucial role in cell proliferation, differentiation and death.[7]
In a 2014review article of thegenome-wide association findings ofalcohol dependence, the researchers concluded that based on functional analysis (demonstration of a cause-effect relation),[8] genetic variants related to the PKNOX2 gene may play a role in alcohol dependence risk, albeit a minor role comparing to the role played by the genes located in the alcohol dehydrogenase cluster.[9]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Imoto I, Sonoda I, Yuki Y, Inazawa J (September 2001). "Identification and characterization of human PKNOX2, a novel homeobox-containing gene".Biochemical and Biophysical Research Communications.287 (1):270–6.doi:10.1006/bbrc.2001.5578.PMID11549286.
^ab"PKNOX2 PBX/knotted 1 homeobox 2 - Gene - GTR - NCBI".www.ncbi.nlm.nih.gov. National Center for Biotechnology Information. Retrieved31 August 2020.Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain This article incorporates text from this source, which is in thepublic domain.
This article incorporates text from this source, which is in thepublic domain.
