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PHF21A

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
PHF21A
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2PUY,2YQL

Identifiers
AliasesPHF21A, BHC80, BM-006, PHD finger protein 21A, NEDMS, IDDBCS
External IDsOMIM:608325;MGI:2384756;HomoloGene:9597;GeneCards:PHF21A;OMA:PHF21A - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PHF21A
Genomic location for PHF21A
Band11p11.2Start45,929,319bp[1]
End46,121,454bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PHF21A
Genomic location for PHF21A
Band2|2 E1Start92,093,117bp[2]
End92,364,666bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • blood

  • epithelium of colon

  • ganglionic eminence

  • monocyte

  • buccal mucosa cell

  • sural nerve

  • granulocyte

  • ventricular zone

  • Achilles tendon
Top expressed in
  • genital tubercle

  • tail of embryo

  • Rostral migratory stream

  • spermatocyte

  • ventricular zone

  • medulla of thymus

  • granulocyte

  • aortic valve

  • ascending aorta

  • saccule
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51317

192285

Ensembl

ENSG00000135365

ENSMUSG00000058318

UniProt

Q96BD5

Q6ZPK0

RefSeq (mRNA)
NM_001101802
NM_016621
NM_001352025
NM_001352026
NM_001352027

NM_001352028
NM_001352029
NM_001352030
NM_001352031
NM_001352032

NM_001109690
NM_001109691
NM_138755
NM_001346704
NM_001362829

NM_001362830
NM_001362831
NM_001362832
NM_001362833

RefSeq (protein)
NP_001095272
NP_057705
NP_001338954
NP_001338955
NP_001338956

NP_001338957
NP_001338958
NP_001338959
NP_001338960
NP_001338961

NP_001103160
NP_001103161
NP_001333633
NP_620094
NP_001349758

NP_001349759
NP_001349760
NP_001349761
NP_001349762

Location (UCSC)Chr 11: 45.93 – 46.12 MbChr 2: 92.09 – 92.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 21A is aprotein that in humans is encoded by thePHF21Agene.[5][6][7]

Function

[edit]

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM][7]

Interactions

[edit]

PHF21A has been shown tointeract with:

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000135365Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000058318Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000)."Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Res.7 (6):347–55.doi:10.1093/dnares/7.6.347.PMID 11214970.
  6. ^abcdeHakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002)."A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes".Proc. Natl. Acad. Sci. U.S.A.99 (11):7420–5.Bibcode:2002PNAS...99.7420H.doi:10.1073/pnas.112008599.PMC 124246.PMID 12032298.
  7. ^ab"Entrez Gene: PHF21A PHD finger protein 21A".
  8. ^abcdIwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression".Biochem. Biophys. Res. Commun.322 (2):601–8.doi:10.1016/j.bbrc.2004.07.163.PMID 15325272.
  9. ^Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003)."A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes".J. Biol. Chem.278 (9):7234–9.doi:10.1074/jbc.M208992200.PMID 12493763.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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