Platelet-derived growth factor C, also known asPDGF-C, is a 345-amino acidprotein that in humans is encoded by thePDGFCgene.[5][6] Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.[7]
The protein encoded by this gene is a member of theplatelet-derived growth factor family. The four members of this family aremitogenic factors for cells ofmesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusualN-terminal domain, theCUB domain.[6]
PDGF-C is a key component of thePDGFR-α signaling pathway and has a specific role inpalatogenesis and themorphogenesis of theintegumentary tissue. The phenotypes of compound mutants imply that PDGF-C and PDGF-A may function as principal ligands for PDGFR-α.[8]
Mouse knockout studies show that PDGF-C is required forpalatogenesis. Although human studies support an etiologic role for several genes incleft lip and palate etiology (PVRL1,IRF6, andMSX1), expression levels of the mouse homologs of these genes were unaltered in Pdgfc−/− mutant embryos that develop clefts, suggesting that their activity is not related to PDGF-C signaling in palatogenesis, so PDGF-C signaling is a new pathway in palatogenesis.[9]
PDGF-C is a latent growth factor with proteolytic activation, and the processing enzyme might be controlled by the other CLP-associated genes that may indirectly connect to PDGF-C signaling. Notably, a 30-cM region on human chromosome 4, where the PDGFC gene maps, shows strong linkage association with CLP26, and clinical genetic data further suggest a potential link between PDGFC gene polymorphism and cleft lip and palate.[8]
^Li X, Pontén A, Aase K, Karlsson L, Abramsson A, Uutela M, Bäckström G, Hellström M, Boström H, Li H, Soriano P, Betsholtz C, Heldin CH, Alitalo K, Ostman A, Eriksson U (May 2000). "PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor".Nat. Cell Biol.2 (5):302–9.doi:10.1038/35010579.PMID10806482.S2CID25066476.
Li X, Pontén A, Aase K, et al. (2000). "PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor".Nat. Cell Biol.2 (5):302–9.doi:10.1038/35010579.PMID10806482.S2CID25066476.
Tsai YJ, Lee RK, Lin SP, Chen YH (2000). "Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract".Biochim. Biophys. Acta.1492 (1):196–202.doi:10.1016/s0167-4781(00)00066-x.PMID11004490.
Andrae J, Molander C, Smits A, et al. (2002). "Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells".Biochem. Biophys. Res. Commun.296 (3):604–11.doi:10.1016/S0006-291X(02)00917-8.PMID12176024.
Jinnin M, Ihn H, Mimura Y, et al. (2005). "Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts".J. Cell. Physiol.202 (2):510–7.doi:10.1002/jcp.20154.PMID15389578.S2CID33954371.
Reigstad LJ, Martinez A, Varhaug JE, Lillehaug JR (2006). "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines".Exp. Cell Res.312 (6):782–95.doi:10.1016/j.yexcr.2005.11.035.PMID16443219.
