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P2RX5

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
P2RX5
Identifiers
AliasesP2RX5, LRH-1, P2X5, P2X5R, purinergic receptor P2X 5
External IDsOMIM:602836;MGI:2137026;HomoloGene:1924;GeneCards:P2RX5;OMA:P2RX5 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for P2RX5
Genomic location for P2RX5
Band17p13.2Start3,672,199bp[1]
End3,696,240bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for P2RX5
Genomic location for P2RX5
Band11|11 B4Start73,051,247bp[2]
End73,063,511bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • lymph node

  • appendix

  • granulocyte

  • mucosa of ileum

  • blood

  • apex of heart

  • gastrocnemius muscle

  • bone marrow cells

  • glutes
Top expressed in
  • brown adipose tissue

  • soleus muscle

  • masseter muscle

  • facial motor nucleus

  • ascending aorta

  • intercostal muscle

  • myocardium of ventricle

  • motor neuron

  • muscle of thigh

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5026

94045

Ensembl

ENSG00000083454

ENSMUSG00000005950

UniProt

Q93086

n/a

RefSeq (mRNA)

NM_175081
NM_001204519
NM_001204520
NM_002561
NM_175080

NM_033321
NM_001376982
NM_001376983

RefSeq (protein)

NP_001191448
NP_001191449
NP_002552
NP_778255

n/a

Location (UCSC)Chr 17: 3.67 – 3.7 MbChr 11: 73.05 – 73.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2X purinoceptor 5 is aprotein in humans that is encoded by theP2RX5gene.[5][6]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000083454Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000005950Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system".FEBS Lett.418 (1–2):195–9.doi:10.1016/S0014-5793(97)01380-X.PMID 9414125.S2CID 42070561.
  6. ^ab"Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5".

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cys-loop receptors
5-HT/serotonin
GABA
Glycine
Nicotinic acetylcholine
Zinc
Ionotropicglutamates
Ligand-gated only
Voltage- and ligand-gated
‘Orphan’
ATP-gated channels
Purinergic receptors
Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others


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