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P2RX2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

P2RX2

Identifiers

Aliases

P2RX2, DFNA41, P2X2, purinergic receptor P2X 2

External IDs

OMIM:600844;MGI:2665170;HomoloGene:14251;GeneCards:P2RX2;OMA:P2RX2 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q24.33	Start	132,618,776bp^[1]
Band	12q24.33	End	132,622,388bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 F	Start	110,487,678bp^[2]
Band	5\|5 F	End	110,491,078bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastric mucosa

right lung

right uterine tube

prostate

caput epididymis

tail of epididymis

corpus epididymis

hippocampus proper

spleen

upper lobe of left lung

Top expressed in

vestibular membrane of cochlear duct

otolith organ

utricle

seminiferous tubule

spermatocyte

ganglion of vagus nerve

spermatid

vestibular sensory epithelium

cochlea

embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	purinergic nucleotide receptor activity extracellularly ATP-gated cation channel activity ion channel activity ligand-gated ion channel activity identical protein binding ATP binding ATP-gated ion channel activity
Cellular component	integral component of membrane membrane receptor complex integral component of nuclear inner membrane integral component of plasma membrane intracellular anatomical structure apical plasma membrane plasma membrane postsynapse soma
Biological process	peristalsis response to ATP positive regulation of calcium-mediated signaling response to hypoxia positive regulation of calcium ion transport into cytosol urinary bladder smooth muscle contraction hearing ion transport response to organic substance cation transmembrane transport neuromuscular synaptic transmission behavioral response to pain neuromuscular junction development skeletal muscle fiber development detection of hypoxic conditions in blood by carotid body chemoreceptor signaling protein homooligomerization response to carbohydrate sensory perception of taste chemical synaptic transmission blood coagulation purinergic nucleotide receptor signaling pathway excitatory postsynaptic potential response to ischemia cation transport ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


22953


231602

Ensembl


ENSG00000187848


ENSMUSG00000029503

UniProt


Q9UBL9


Q8K3P1

RefSeq (mRNA)

NM_001282164 NM_001282165 NM_012226 NM_016318 NM_170682
NM_170683 NM_174872 NM_174873


NM_001164833 NM_001164834 NM_153400 NM_001310700 NM_001310701

RefSeq (protein)

NP_001269093 NP_001269094 NP_036358 NP_057402 NP_733782
NP_733783 NP_777361 NP_777362


NP_001158305 NP_001158306 NP_001297629 NP_001297630 NP_700449

Location (UCSC)

Chr 12: 132.62 – 132.62 Mb

Chr 5: 110.49 – 110.49 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

P2X purinoceptor 2 is aprotein that in humans is encoded by theP2RX2gene.^[5]^[6]^[7]

The product of this gene belongs to the family ofpurinoceptors forATP. This receptor functions as a cation conductingligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000187848 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000029503 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors".Mol Pharmacol.56 (6):1171–81.doi:10.1124/mol.56.6.1171.PMID 10570044.
^Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor".Nature.371 (6497):519–23.Bibcode:1994Natur.371..519B.doi:10.1038/371519a0.PMID 7523952.S2CID 4371044.
^^a ^b"Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2".

External links

[edit]

P2RX2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Ion channel,cell surface receptor:ligand-gated ion channels

Cys-loop receptors

5-HT/serotonin	5-HT₃ A B C D E
GABA	GABA_A α₁ α₂ α₃ α₄ α₅ α₆ β₁ β₂ β₃ γ₁ γ₂ γ₃ δ ε π θ GABA_A-ρ ρ₁ ρ₂ ρ₃
Glycine	α₁ α₂ α₃ α₄ β
Nicotinic acetylcholine	monomers:α1 α2 α3 α4 α5 α6 α7 α9 α10 β1 β2 β3 β4 δ ε pentamers:(α3)₂(β4)₃ (α4)₂(β2)₃ (α7)₅ (α1)₂(β4)₃ - Ganglion type (α1)₂β1δε - Muscle type
Zinc	Zinc-activated

Ionotropic glutamates

Ligand-gated only	AMPA (1 2 3 4) Kainate 1 2 3 4 5
Voltage- and ligand-gated	NMDA 1 2A 2B 2C 2D 3A 3B L1A L1B
‘Orphan’	GluD δ₁ δ₂

ATP-gated channels

Purinergic receptors	P2X 1 2 3 4 5 6 7

Purine receptor modulators

Receptor
(ligands)

P0 (adenine)

Agonists:8-Aminoadenine
Adenine

P1
(adenosine)

P2
(nucleotide)

P2X
(ATPTooltip Adenosine triphosphate)

P2Y

Transporter
(blockers)

CNTsTooltip Concentrative nucleoside transporters	6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone
ENTsTooltip Equilibrative nucleoside transporters	Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline
PMATTooltip Plasma membrane monoamine transporter	Decynium-22

Enzyme
(inhibitors)

XOTooltip Xanthine oxidase	Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat
Others	Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others