P2X purinoceptor 1, alsoATP receptor, is aprotein that in humans is encoded by theP2RX1gene.[5]
The product of this gene belongs to the family ofpurinoceptors forATP. This receptor functions as aligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder".Receptors Channels.3 (4):283–9.PMID8834001.
Dhulipala PD, Lianos EA, Kotlikoff MI (2001). "Regulation of human P2X1 promoter activity by beta helix-loop-helix factors in smooth muscle cells".Gene.269 (1–2):167–75.doi:10.1016/S0378-1119(01)00442-5.PMID11376948.
Ennion SJ, Evans RJ (2002). "Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface".Mol. Pharmacol.61 (2):303–11.doi:10.1124/mol.61.2.303.PMID11809854.
Oury C, Toth-Zsamboki E, Thys C, et al. (2003). "The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen".Thromb. Haemost.86 (5):1264–71.PMID11816716.
Rolf MG, Mahaut-Smith MP (2003). "Effects of enhanced P2X1 receptor Ca2+ influx on functional responses in human platelets".Thromb. Haemost.88 (3):495–502.doi:10.1055/s-0037-1613243.PMID12353081.S2CID41234874.
Valdecantos P, Briones R, Moya P, et al. (2003). "Pharmacological identification of P2X1, P2X4 and P2X7 nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels".Placenta.24 (1):17–26.doi:10.1053/plac.2002.0862.PMID12495655.
Vial C, Pitt SJ, Roberts J, et al. (2004). "Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis".Blood.102 (10):3646–51.doi:10.1182/blood-2003-06-1963.PMID12907444.S2CID22284207.
