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Octreotate

From Wikipedia, the free encyclopedia
Octreotate
Identifiers
3D model (JSmol)
  • InChI=1S/C49H64N10O11S2/c1-27(60)40-48(68)57-39(47(67)59-41(28(2)61)49(69)70)26-72-71-25-38(56-42(62)33(51)21-29-13-5-3-6-14-29)46(66)54-36(22-30-15-7-4-8-16-30)44(64)55-37(23-31-24-52-34-18-10-9-17-32(31)34)45(65)53-35(43(63)58-40)19-11-12-20-50/h3-10,13-18,24,27-28,33,35-41,52,60-61H,11-12,19-23,25-26,50-51H2,1-2H3,(H,53,65)(H,54,66)(H,55,64)(H,56,62)(H,57,68)(H,58,63)(H,59,67)(H,69,70)/t27-,28-,33-,35+,36+,37-,38+,39+,40+,41+/m1/s1
    Key: KEKAEHDXIJNAIJ-WNIOSIORSA-N
  • C[C@@H](O)[C@H](NC (=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(=O)O
Properties
C49H64N10O11S2
Molar mass1033.23 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Octreotate oroctreotide acid is asomatostatin analogue that is closely related tooctreotide. Itsamino acid sequence is

H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-OH

while octreotide has the terminalthreonine reduced to the corresponding amino alcohol.

See also

[edit]

References

[edit]
  • Laznicek, M.; Laznickova, A.; Mäcke, H. R.; Eisenwiener, K.; Reubi, J. C.; Wenger, S. (2002). "Octreotide and Octreotate Derivatives Radiolabeled with Yttrium: Pharmacokinetics in Rats".Cancer Biotherapy & Radiopharmaceuticals.17 (5):527–533.doi:10.1089/108497802760804754.PMID 12470422.
GH
(somatotropin)
GHIH
(somatostatin)
GHRH
(somatocrinin)
GHS
(ghrelin)
IGF-1
(somatomedin)


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