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NDST1

From Wikipedia, the free encyclopedia
Enzyme
NDST1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1NST

Identifiers
AliasesNDST1, HSST, NST1, MRT46, N-deacetylase/N-sulfotransferase 1, N-deacetylase and N-sulfotransferase 1
External IDsOMIM:600853;MGI:104719;HomoloGene:20386;GeneCards:NDST1;OMA:NDST1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for NDST1
Genomic location for NDST1
Band5q33.1Start150,485,818bp[1]
End150,558,211bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for NDST1
Genomic location for NDST1
Band18|18 E1Start60,817,566bp[2]
End60,881,722bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • C1 segment

  • olfactory bulb

  • subthalamic nucleus

  • inferior ganglion of vagus nerve

  • right lobe of liver

  • lateral nuclear group of thalamus

  • mucosa of esophagus

  • inferior olivary nucleus

  • upper lobe of left lung
Top expressed in
  • right lung lobe

  • left lung

  • left lung lobe

  • lacrimal gland

  • epithelium of stomach

  • left lobe of liver

  • human fetus

  • salivary gland

  • vas deferens

  • digastric muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3340

15531

Ensembl

ENSG00000070614

ENSMUSG00000054008

UniProt

P52848

Q3UHN9

RefSeq (mRNA)

NM_001301063
NM_001543

NM_008306
NM_001348100
NM_001348101
NM_001348102
NM_001348103

NM_001348146

RefSeq (protein)

NP_001287992
NP_001534

NP_032332
NP_001335029
NP_001335030
NP_001335031
NP_001335032

NP_001335075

Location (UCSC)Chr 5: 150.49 – 150.56 MbChr 18: 60.82 – 60.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is anenzyme. Inhumans, it is encoded by theNDST1gene.[5][6][7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000070614Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000054008Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ (Aug 1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1".Genomics.26 (2):239–44.doi:10.1016/0888-7543(95)80206-2.PMID 7601448.
  6. ^Humphries DE, Sullivan BM, Aleixo MD, Stow JL (Aug 1997)."Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network".Biochem J. 325. ( Pt 2) (2):351–7.doi:10.1042/bj3250351.PMC 1218567.PMID 9230113.
  7. ^"Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1".

Further reading

[edit]
PDB gallery
  • 1nst: THE SULFOTRANSFERASE DOMAIN OF HUMAN HAPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE
    1nst: THE SULFOTRANSFERASE DOMAIN OF HUMAN HAPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE


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