Napsin-A is anaspartic proteinase that is encoded in humans by theNAPSAgene.[5] The name napsin comes fromnovelasparticproteinase of thepepsin family.[6]
The activation peptide of an aspartic proteinase acts as an inhibitor of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinasezymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Itstranslation product is predicted to be a fully functional,glycosylated aspartic proteinase precursor containing anRGD motif and an additional 18 residues at itsC-terminus.[5]
Cook M, Bühling F, Ansorge S, et al. (2002). "Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells".Biochim. Biophys. Acta.1577 (1):10–6.doi:10.1016/s0167-4781(02)00400-1.PMID12151090.
Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex".Nat. Cell Biol.6 (4):319–27.doi:10.1038/ncb1105.PMID15048123.S2CID22767022.
