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| Clinical data | |
|---|---|
| Trade names | Aphexda |
| Other names | BL-8040 |
| AHFS/Drugs.com | Monograph |
| License data | |
| Routes of administration | Subcutaneous |
| Drug class | Antineoplastic |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number |
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| PubChemCID | |
| DrugBank | |
| ChemSpider | |
| UNII |
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| KEGG | |
| ChEBI | |
| Chemical and physical data | |
| Formula | C97H144FN33O19S2 |
| Molar mass | 2159.55 g·mol−1 |
Motixafortide, sold under the brand nameAphexda, is amedication used for the treatment ofmultiple myeloma.[1] Motixafortide is ahematopoietic stem cell mobilizer and aCXCR4 antagonist.[1] It is given bysubcutaneous injection.[1]
The most common side effects include injection site reactions, pruritus, flushing, and back pain.[3]
Motixafortide was approved for medical use in the United States in September 2023.[3][4][5]
Motixafortide isindicated, in combination withfilgrastim, agranulocyte-colony stimulating factor (G-CSF), to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequentautologous transplantation in people with multiple myeloma.[1][3][4]
Motixafortide can cause injection site reactions, anaphylactic shock, and hypersensitivity reactions.[3] Tumor cell mobilization in people with leukemia, leukocytosis, potential for tumor cell mobilization, and embryo-fetal toxicity can also be caused by motixafortide.[3]
The USFood and Drug Administration (FDA) approved motixafortide based on evidence from the GENESIS study, a double-blind, placebo-controlled study, in which 122 participants with multiple myeloma, due to undergo autologous transplantation, were randomized 2:1 to receive motixafortide 1.25 mg/kg with granulocyte-colony stimulating factor (N=80) or placebo with granulocyte-colony stimulating factor (N=42) for mobilization of hematopoietic stem cells for collection and apheresis.[3] This one trial evaluated the benefit and side effects of motixafortide in participants.[3] The trial was conducted at 21 sites in five countries including Italy, Hungary, Germany, Spain, and the United States.[3] There were 78 participants included in the trial from the United States, and 44 participants included from sites outside of the United States.[3] The GENESIS trial was used to assess efficacy and safety.[3]
Motixafortide is theinternational nonproprietary name.[6]
This article incorporates text from this source, which is in thepublic domain. This article incorporates text from this source, which is in thepublic domain.