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TheMalpighian layer (stratum mucosum orstratum malpighii) of theepidermis is generally defined as both thestratum basale (basal layer) and the thickerstratum spinosum (spinous layer/prickle cell layer) immediately above it as a single unit,[1][2] although it is occasionally defined as the stratum basale specifically,[3] or the stratum spinosum specifically.[4]
It is named after the Italian biologist and physicianMarcello Malpighi.
Basal cell carcinoma originates from the basal layer of the stratum malpighii.
This layer is where almost all of themitotic activity in theepidermis occurs. The activity of these cells is increased by IL-1 (interleukin-1) andepidermal growth factor. The activity is decreased bytransforming growth factor beta.[5]
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