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Lithium citrate

From Wikipedia, the free encyclopedia
Chemical used in psychiatric treatment
Lithium citrate
Names
Other names
Trilithium citrate
trilithium 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard100.011.860Edit this at Wikidata
EC Number
  • 213-045-8
RTECS number
  • TZ8616000
UNII
  • InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 checkY
    Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K checkY
  • InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
    Key: WJSIUCDMWSDDCE-DFZHHIFOAV
  • [Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]
Properties
Li3C6H5O7
Molar mass209.923 g mol−1
AppearanceOdorless white powder
Melting pointdecomposes at 105 °C (221 °F; 378 K)
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H302,H319
P305+P351+P338
Flash pointN/A
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

Lithium citrate (Li3C6H5O7) is alithium salt ofcitric acid that is used as amood stabilizer in psychiatric treatment ofmanic states andbipolar disorder.[1][2][3][4] There is extensivepharmacology of lithium, the active component of this salt.

Lithia water contains various lithium salts, including the citrate.

History

[edit]

An early version ofCoca-Cola available in pharmacies' soda fountains called Lithia Coke was a mixture of Coca-Cola syrup andlithia water. Thesoft drink7Up was originally named "Bib-Label Lithiated Lemon-Lime Soda" when it was formulated in 1929 because it contained lithium citrate. The beverage was apatent medicine marketed as a cure forhangover. Lithium citrate was removed from 7Up in 1948[5] after theFood and Drug Administration banned its use in soda.[6]

Lithium citrate is used as a mood stabilizer and is used to treatmania,hypomania,depression andbipolar disorder.[7] It can be administered orally in the form of a syrup.[7]

References

[edit]
  1. ^Medication description
  2. ^"pms-Lithium Citrate - Uses, Side Effects, Interactions - MedBroadcast.com".medbroadcast.com. Retrieved2017-08-15.
  3. ^"Medical use". Archived fromthe original on 2006-06-15. Retrieved2006-07-29.
  4. ^"Lithium: medicine to control mood disorders such as mania and bipolar disorder".nhs.uk. 2020-08-17. Retrieved2022-08-25.
  5. ^Gielen, Marcel; Edward R. T. Tiekink (2005).Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine. John Wiley and Sons. p. 3.ISBN 0-470-86403-6.
  6. ^"Here's the Gross Thing That Happens when You Mix 7-Up with Lithium". Time, Inc. 2016-02-20. Retrieved2024-12-11.
  7. ^abPubChem."Lithium citrate".pubchem.ncbi.nlm.nih.gov. Retrieved2022-09-08.


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