Laudanosine orN-methyltetrahydropapaverine is a recognized metabolite[1] ofatracurium andcisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses ofcisatracurium oratracurium.
Capsule ofPapaver somniferum showing latex (opium) exuding from incision. Laudanosine occurs naturally in small amounts (0.1%) in opium.
Laudanosine also occurs naturally in minute amounts (0.1%) inopium, from which it was first isolated in 1871.[2] Partialdehydrogenation of laudanosine will lead topapaverine, the alkaloid found in the opium poppy plant (Papaver somniferum).
^abFodale V, Santamaria LB (July 2002). "Laudanosine, an atracurium and cisatracurium metabolite".Eur J Anaesthesiol.19 (7):466–73.doi:10.1017/s0265021502000777 (inactive 1 November 2024).PMID12113608.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
^Katz Y, Weizman A, Pick CG, Pasternak GW, Liu L, Fonia O, Gavish M (May 1994). "Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity".Brain Res.646 (2):235–241.doi:10.1016/0006-8993(94)90084-1.PMID8069669.S2CID35031924.
^Katz Y, Gavish M (Jan 1989). "Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors".Anesthesiology.70 (1):109–111.doi:10.1097/00000542-198901000-00020.PMID2536252.
