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Ladostigil

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Ladostigil
Clinical data
Other namesTV-3326; (N-Propargyl-(3R)-aminoindan-5-yl)-N-propylcarbamate
Routes of
administration
Oral
ATC code
  • None
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • [(3R)-3-(prop-2-ynylamino)indan-5-yl]-N-propylcarbamate
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H20N2O2
Molar mass272.348 g·mol−1

Ladostigil (developmental code nameTV-3326) is a novelneuroprotectiveagent being investigated for the treatment ofneurodegenerative disorders likeAlzheimer's disease,Lewy body disease, andParkinson's disease.[1][2] It was developed fromstructural modification ofrasagiline.[3]

The drug acts as areversibleacetylcholinesterase andbutyrylcholinesteraseinhibitor, and anirreversiblemonoamine oxidase Binhibitor, and combines themechanisms of action of older drugs likerivastigmine andrasagiline into a single molecule.[4][5] In addition to its neuroprotective properties, ladostigil enhances the expression ofneurotrophic factors likeGDNF andBDNF, and may be capable of reversing some of the damage seen in neurodegenerative diseases via the induction ofneurogenesis.[6] Ladostigil also hasantidepressant-like effects in animals, and may be useful for treating comorbiddepression andanxiety often seen in such diseases as well.[7][8]

There have been no new updates on the pharmaceutical development of ladostigil since 2019.[1] At this time, it was inphase 2clinical trials for Alzheimer's disease.[1]

See also

[edit]

References

[edit]
  1. ^abc"Ladostigil - Avraham Pharmaceuticals".AdisInsight. 3 August 2022. Retrieved17 August 2024.
  2. ^Weinstock M, Bejar C, Wang RH, et al. (2000). "TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease".Advances in Research on Neurodegeneration. pp. 157–69.doi:10.1007/978-3-7091-6301-6_10.ISBN 978-3-211-83537-1.PMID 11205137.{{cite book}}:|journal= ignored (help)
  3. ^Chen JJ, Swope DM (August 2005)."Clinical pharmacology of rasagiline: a novel, second-generation propargylamine for the treatment of Parkinson disease".Journal of Clinical Pharmacology.45 (8):878–894.doi:10.1177/0091270005277935.PMID 16027398.S2CID 24350277. Archived fromthe original on 11 July 2012.
  4. ^Weinreb O, Mandel S, Bar-Am O, et al. (January 2009)."Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs".Neurotherapeutics.6 (1):163–74.doi:10.1016/j.nurt.2008.10.030.PMC 5084264.PMID 19110207.
  5. ^Weinstock M, Luques L, Bejar C, Shoham S (2006). "Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression".Parkinson's Disease and Related Disorders. pp. 443–6.doi:10.1007/978-3-211-45295-0_67.ISBN 978-3-211-28927-3.PMID 17017566.{{cite book}}:|journal= ignored (help)
  6. ^Weinreb O, Amit T, Bar-Am O, Youdim MB (December 2007). "Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy".Annals of the New York Academy of Sciences.1122 (1):155–68.Bibcode:2007NYASA1122..155W.doi:10.1196/annals.1403.011.PMID 18077571.S2CID 39753711.
  7. ^Weinstock M, Poltyrev T, Bejar C, Youdim MB (March 2002). "Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression".Psychopharmacology.160 (3):318–24.doi:10.1007/s00213-001-0978-x.PMID 11889501.S2CID 26001621.
  8. ^Weinstock M, Gorodetsky E, Poltyrev T, Gross A, Sagi Y, Youdim M (June 2003). "A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease".Progress in Neuro-psychopharmacology & Biological Psychiatry.27 (4):555–61.doi:10.1016/S0278-5846(03)00053-8.PMID 12787840.S2CID 21612561.
Food antioxidants
Fuel antioxidants
Measurements
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
Enhancers
Non-specific
AAADTooltip Aromatic L-amino acid decarboxylase
MAOTooltip Monoamine oxidase
Phenethylamines
(dopamine,epinephrine,
norepinephrine)
PAHTooltip Phenylalanine hydroxylase
THTooltip Tyrosine hydroxylase
DBHTooltip Dopamine beta-hydroxylase
PNMTTooltip Phenylethanolamine N-methyltransferase
COMTTooltip Catechol-O-methyl transferase
Tryptamines
(serotonin,melatonin)
TPHTooltip Tryptophan hydroxylase
AANATTooltip Serotonin N-acetyl transferase
ASMTTooltip Acetylserotonin O-methyltransferase
Histamine
HDCTooltip Histidine decarboxylase
HNMTTooltip Histamine N-methyltransferase
DAOTooltip Diamine oxidase
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