LRRIQ3
Identifiers
Aliases	LRRIQ3, LRRC44, leucine-rich repeats and IQ motif containing 3, leucine rich repeats and IQ motif containing 3
External IDs	OMIM:617957;MGI:1921685;HomoloGene:23668;GeneCards:LRRIQ3;OMA:LRRIQ3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 74,026,015bp[1] End 74,198,187bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H4 Start 154,799,071bp[2] End 154,899,917bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis buccal mucosa cell gonad sperm secondary oocyte bronchial epithelial cell right uterine tube mucosa of paranasal sinus Top expressed in spermatid spermatocyte seminiferous tubule zygote gastrula secondary oocyte primary oocyte lumbar spinal ganglion lumbar subsegment of spinal cord submandibular gland More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 127255 74435 Ensembl ENSG00000162620 ENSMUSG00000028182 UniProt A6PVS8 H0Y5F9 Q14DL3 RefSeq (mRNA) NM_001105659 NM_145258 NM_001322315 NM_028938 RefSeq (protein) NP_001099129 NP_001309244 NP_083214 Location (UCSC) Chr 1: 74.03 – 74.2 Mb Chr 3: 154.8 – 154.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LRRIQ3 (Leucine-rich repeats and IQ motif containing 3), which is also known as LRRC44, is aprotein that in humans is encoded by the LRRIQ3gene.^[5] It is predominantly expressed in the testes, and is linked to a number of diseases.^[6]

LRRIQ3 is found on theminus strand of the end of theshort arm of humanchromosome 1 at 1p31.1.^[7]

There are a total of 7exons in the putative sequence of LRRIQ3.^[7]

LRRIQ3 is expressed as 2 primaryisoforms, which produce proteins of length 624 amino acids and 464 amino acids respectively.^[7] It is expressed at low levels in human and brown rat tissues,^[8][9] with highest expression levels intestes tissue. There are relatively high expression levels inT cells, theepididymis, thekidney, and a number of glands.^[10]

Human protein LRRIQ3 Isoform 1 consists of 624 amino acids, and has a molecular weight of 73.7 kDa. The isoelectric point of LRRIQ3 is 9.73, which suggests that LRRIQ3 isbasic at normal physiological pH (~7.4).^[11] Additionally, there is strong evidence that human LRRIQ3 localizes to the plasma membrane from antibody staining.^[12] LRRIQ3 is rich inlysine residues, with a total of 82 lysines. It is also slightly low onglycines.^[13]

In total, there are 4conserved domains within LRRIQ3: 3leucine-rich repeats and 1IQ calmodulin-binding motif.^[13] Leucine-rich repeats are typically involved in protein-protein interactions, and form a characteristic α/β horseshoefold.^[14][15] An IQ motif provides a binding site for calmodulin (CaM) or CaM-like proteins.^[16]

LRRIQ3 is predicted to be mostlyalpha-helical instructure, including a long alpha-helicalC-terminal domain. It is also predicted to function as amonomer.^{[17][18][19][20]}

LRRIQ3 is predicted to undergo manypost-translational modifications. These includeO-GlcNAcylation,SUMOylation,ubiquitination, andphosphorylation.^[22][23] LRRIQ3 is predicted to have 4 well conserved SUMOylation sites and 1 well conserved ubiquitination site.^[22] A representation of these post-translational modifications is shown in the figure below.

There is evidence that LRRIQ3 interacts with a number of proteins fromtwo-hybrid assays andaffinity chromatography. The proteins LRRIQ3 interact with includeLYN,NCK2,GNB4, andABL1.^[25][26] These proteins are associated withcell signalling,cytoskeletal reorganization, andcell differentiation, as well as others.^{[27][28][29][30]}

Noparalogs exists for LRRIQ3 in humans.^[6] However, there are a number oforthologs, as reported byBLAST, some of which are listed below.^[31] The number of years sincedivergence from the human protein, listed in "million of years ago (MYA)" below, were calculated usingTimeTree.^[32]

LRRIQ3 is linked to a number of cancers. RNA-seq experiments have shown that LRRIQ3 is severely down-regulated (Log₂-fold changes between -3.4 and -4.2) in a number of disease states, including pancreatic cancer, colorectal cancer, and breast cancer.^[33][34][35]

• Genes on human chromosome 1
• Proteins

• CS1 errors: generic name
• Articles with short description
• Short description matches Wikidata