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| Formula | C18H26Cl2N2 |
| Molar mass | 341.32 g·mol−1 |
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LR132 or(+)-3,4-dichloro-N-[(1R,2S)-2-(1-pyrrolidinyl)cyclohexyl]benzeneethanamine is a selectivesigma receptorantagonist, with a reportedbinding affinity ofKi = 2 ± 0.1 nM for thesigma-1 receptor and more than 350 times selectivity over thesigma-2 receptor.[1]
Consistent with other reportedsigma receptorantagonists, pretreating Swiss Webster mice with LR132 significantly decreases the convulsivity and lethality ofcocaine.[1]
