There are approximately 40 known eukaryotic LIM proteins, so named for theLIM domains they contain. LIM domains are highly conservedcysteine-rich structures containing 2zinc fingers. Although zinc fingers usually function by binding toDNA orRNA, the LIM motif probably mediatesprotein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2N-terminal LIM motifs, a centralPDZ domain, and aC-terminalprotein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development.[7]
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Mizuno K, Okano I, Ohashi K, Nunoue K, Kuma K, Miyata T, Nakamura T (1994). "Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif".Oncogene.9 (6):1605–12.PMID8183554.
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization".Nature.393 (6687):809–12.Bibcode:1998Natur.393..809Y.doi:10.1038/31735.PMID9655398.S2CID4326365.
Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex".Nat. Genet.22 (4):394–9.doi:10.1038/11970.PMID10431247.S2CID22326394.
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase".Science.285 (5429):895–8.doi:10.1126/science.285.5429.895.PMID10436159.
Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics".Nat. Cell Biol.1 (5):253–9.doi:10.1038/12963.PMID10559936.S2CID25250183.
Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF (2000). "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23".Mamm. Genome.11 (10):890–8.doi:10.1007/s003350010166.PMID11003705.S2CID8575994.
