Imidazo[1,2-a]pyridine—an example of imidazopyridine and a core structure ofzolpidem and some compounds described below.
Animidazopyridine is a nitrogen containingheterocycle that is also a class ofdrugs that contain this same chemical substructure. In general, they areGABAA receptoragonists, however recentlyproton pump inhibitors,aromatase inhibitors,NSAIDs and other classes of drugs in this class have been developed as well. Despite usually being similar to them in effect, they are not chemically related to benzodiazepines. As such, GABAA-agonizing imidazopyridines,pyrazolopyrimidines, andcyclopyrrones are sometimes grouped together and referred to as "nonbenzodiazepines." Imidazopyridines include:
SCH28080—the prototypical potassium-competitive acid blocker which has not found clinical use because of liver toxicity in animal trials and elevated liver enzyme activity in the serum of human volunteers.[7]
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^Belohlavek D, Malfertheiner P (1979). "The effect of zolimidine, imidazopyridine-derivate, on the duodenal ulcer healing".Scandinavian Journal of Gastroenterology. Supplement.54: 44.PMID161649.
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^Melis, Maria Rosaria; Succu, Salvatora; Sanna, Fabrizio; Melis, Tiziana; Mascia, Maria Stefania; Enguehard‐Gueiffier, Cécile; Hubner, Harald; Gmeiner, Peter; Gueiffier, Alain; Argiolas, Antonio (2006). "PIP3EA and PD‐168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain".European Journal of Neuroscience.24 (7):2021–2030.doi:10.1111/j.1460-9568.2006.05043.x.ISSN0953-816X.
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