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IL36B

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

IL36B

Identifiers

Aliases

IL36B, FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, interleukin 36, beta, interleukin 36 beta

External IDs

OMIM:605508;MGI:1916927;HomoloGene:18278;GeneCards:IL36B;OMA:IL36B - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q14.1	Start	113,022,089bp^[1]
Band	2q14.1	End	113,052,867bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 A3\|2 16.21 cM	Start	24,043,173bp^[2]
Band	2 A3\|2 16.21 cM	End	24,050,531bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of leg

skin of abdomen

islet of Langerhans

tonsil

stromal cell of endometrium

vagina

head

mouth

exocrine gland

oral mucosa

Top expressed in

esophagus

skin of external ear

cervix

umbilical cord

lumbar subsegment of spinal cord

trachea

granulocyte

skin of abdomen

digastric muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cytokine activity interleukin-1 receptor binding
Cellular component	extracellular region extracellular space
Biological process	innate immune response inflammatory response immune response immune system process regulation of signaling receptor activity cytokine-mediated signaling pathway neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of T cell differentiation positive regulation of JNK cascade cellular response to lipopolysaccharide
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


27177


69677

Ensembl


ENSG00000136696


ENSMUSG00000026985

UniProt


Q9NZH7


Q9D6Z6

RefSeq (mRNA)


NM_014438 NM_173178


NM_027163

RefSeq (protein)


NP_055253 NP_775270


NP_081439

Location (UCSC)

Chr 2: 113.02 – 113.05 Mb

Chr 2: 24.04 – 24.05 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interleukin-36 beta also known asinterleukin-1 family member 8 (IL1F8) is aprotein that in humans is encoded by theIL36Bgene.^[5]^[6]^[7]^[8]

Function

[edit]

The protein encoded by this gene is a member of theinterleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-strandedbeta-trefoil structure that is conserved betweenIL1A (IL-A alpha) andIL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.^[8]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000136696 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000026985 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000)."Four new members expand the interleukin-1 superfamily".J Biol Chem.275 (2):1169–75.doi:10.1074/jbc.275.2.1169.PMID 10625660.
^Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene".Biochem Biophys Res Commun.263 (3):702–6.doi:10.1006/bbrc.1999.1440.PMID 10512743.
^Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C (Jun 2006)."The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes".Arthritis Research & Therapy.8 (3): R80.doi:10.1186/ar1946.PMC 1526623.PMID 16646978.
^^a ^b"Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta)".

Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes".Genomics.19 (2):382–4.doi:10.1006/geno.1994.1076.PMID 8188271.
Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13".Genomics.41 (3):370–8.doi:10.1006/geno.1997.4654.PMID 9169134.
Kumar S, McDonnell PC, Lehr R, et al. (2000)."Identification and initial characterization of four novel members of the interleukin-1 family".J. Biol. Chem.275 (14):10308–14.doi:10.1074/jbc.275.14.10308.PMID 10744718.
Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2".Genomics.66 (2):213–6.doi:10.1006/geno.2000.6184.PMID 10860666.
Barton JL, Herbst R, Bosisio D, et al. (2001)."A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities".Eur. J. Immunol.30 (11):3299–308.doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S.PMID 11093146.
Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp".Cytokine.13 (1):1–7.doi:10.1006/cyto.2000.0799.PMID 11145836.
Lin H, Ho AS, Haley-Vicente D, et al. (2001)."Cloning and characterization of IL-1HY2, a novel interleukin-1 family member".J. Biol. Chem.276 (23):20597–602.doi:10.1074/jbc.M010095200.PMID 11278614.
Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2".J. Immunol.167 (3):1440–6.doi:10.4049/jimmunol.167.3.1440.PMID 11466363.S2CID 85986577.
Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes".Trends Immunol.22 (10):536–7.doi:10.1016/S1471-4906(01)02040-3.PMID 11574262.
Nicklin MJ, Barton JL, Nguyen M, et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster".Genomics.79 (5):718–25.doi:10.1006/geno.2002.6751.PMID 11991722.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Towne JE, Garka KE, Renshaw BR, et al. (2004)."Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs".J. Biol. Chem.279 (14):13677–88.doi:10.1074/jbc.M400117200.PMID 14734551.
Hillier LW, Graves TA, Fulton RS, et al. (2005)."Generation and annotation of the DNA sequences of human chromosomes 2 and 4".Nature.434 (7034):724–31.Bibcode:2005Natur.434..724H.doi:10.1038/nature03466.PMID 15815621.

Cell signaling:cytokines

By family

Chemokine

CCL	CCL1 CCL2/MCP1 CCL3/MIP1α CCL4/MIP1β CCL5/RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18/PARC/DCCK1/AMAC1/MIP4 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28
CXCL	CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17
CX3CL	CX3CL1
XCL	XCL1 XCL2

TNF

Interleukin

Type I
(grouped by
receptor
subunit)

γ chain	IL2/IL15 IL4/IL13 IL7 IL9 IL21
β chain	IL3 IL5 GMCSF
IL6 like/gp130	IL6 IL11 IL27 IL30 IL31 +non ILOSM LIF CNTF CTF1
IL12 family/IL12RB1	IL12 IL23 IL27 IL35
Other	IL14 IL16 IL32 IL34

Type II

IL10 family

Interferon

I	IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IFNK IFNW1
II	IFNG

Ig superfamily

IL17 family

IL17/IL25 (IL17A)

Other

By function/
cell

proinflammatory cytokine
- IL1
- TNFA

Monokine
Lymphokine
- T_h1
  - IFNγ
  - TNFβ
- T_h2
  - IL4
  - IL5
  - IL6
  - IL10
  - IL13

Interleukin receptor modulators

IL-1

Decoy receptors:Rilonacept (IL-1 Trap)

IL-2

IL-3

IL-4

Antagonists:Pitrakinra

Antibodies:Dupilumab
Pascolizumab

IL-5

Agonists:Interleukin 5

Antagonists:YM-90709

Antisense oligonucleotides:TPI ASM8

IL-6

Agonists:Atexakin alfa
Interleukin 6

IL-7

Agonists:Interleukin 7

IL-8

See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.

IL-9

Agonists:Interleukin 9

Antibodies:Enokizumab

IL-10

Agonists:Ilodecakin
Interleukin 10 (CSIF)

IL-11

Agonists:Interleukin 11 (AGIF)
Oprelvekin

IL-12

Agonists:Edodekin alfa
Interleukin 12

Antibodies:Briakinumab
Ustekinumab

IL-13

IL-15

Agonists:ALT-803
Interleukin 15

IL-17

Agonists:Interleukin 17 (A,B,C,D,E (interleukin 25),F)

IL-18

Binding proteins:IL18BP

IL-20

Antibodies:Fletikumab (against IL-20)

IL-21

Agonists:Denenicokin
Interleukin 21

Antibodies:NNC0114-0005
NNC0114-0006

IL-22

Agonists:Interleukin 22

Antibodies:Fezakinumab (against IL-22)

IL-23

Agonists:Interleukin 23 (SGRF)

IL-27

Agonists:Interleukin 27 (interleukin 30)

IL-28

IL-31

Agonists:Interleukin 31

IL1RL1

Agonists:Interleukin 33

IL1RL2

Agonists:Interleukin 36 (α,β,γ)
Interleukin 38

Antagonists:IL-36RA

Others

JAK	Seehere instead.
Others	Interleukin 14 (taxilin alpha, HMW-BCGF) Interleukin 16 (signals throughCD4) Interleukin 24 (signals throughIL-22Rα1/IL-20Rβ heterodimer) Interleukin 26 (signals throughIL-20Rα/IL-10Rβ heterodimer) Interleukin 32 Interleukin 34 (signals throughM-CSFR/CSF1R) Interleukin 35 Unsorted:Efavaleukin alfa Efineptakin alfa

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